Innogenetics N.v.

N.v. Innogenetics S.a.

Robert J Deleys

Geert Maertens

Dirk Pollet

Hugo Van Heuverswijn

Geert Leroux-Roels

Christine Labeur

Robert Brasseur

Maryvonne Rosseneu

Goort Maertens

The present invention relates to a polypeptide of about 8 to about 100 amino acids comprising or consisting of at least 8 contiguous amino acids selected from the core, and/or the NS3 regions of the HCV polyprotein, with said contiguous amino acids containing a T-cell stimulating epitope.

Immunodominant human T-cell epitopes of hepatitis C virus

The present invention relates to a polypeptide of about 8 to about 100 amino acids containing at least about 8 contiguous amino acids selected from the core, and/or the E1, and/or E2, and/or the NS3 regions of the HCV polyprotein, with the contiguous amino acids containing a T-cell stimulating epitope.

Peptide sequences are provided which are capable of mimicking proteins encoded by HCV for use as reagents for screening of blood and blood products for prior exposure to HCV. The peptides are at least 5 amino acids long and can be used in various specific assays for the detection of antibodies to HCV, for the detection of HCV antigens, or as immunogens.

Synthetic antigens for the detection of antibodies to hepatitis C virus

Peptides and proteins, process for their preparation and their use as

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Grimbergen, Belgium

Robert J Deleys