Applied Biosystems, LLC

The Perkin-elmer Corporation

Robert J DeFranco

David H Lloyd

Victoria L Boyd

MeriLisa Bozzini

Charles S Ladd

A method of forming a thiohydantoin from an N-protected amino acid is described. The method employs a phosphate compound selected from the group consisting of

Thiohydantoin formation and selective modification of the carboxy

A cartridge containing a dry polymer composition carrying trapped biopolymer subunits for use in synthesis of biopolymer chains provides a discrete unit for stepwise supply of subunits, such as protected amino acids, in an automated apparatus for biopolymer synthesis. The composition is swellable in organic solvent to release and supply the subunits to a growing biopolymer chain immobilized on a polymer support. An automated synthesizer uses the cartridges for sequential subunit supply and monitors conductivity of deprotection reagents to control cycling and timing of steps.

Biopolymer synthesis apparatus and method

A polymer composition having a biopolymer subunit entrapped in a swellable polymer matrix is described. The composition may be supplied in a disposable cartridge, for use in delivering a solution of the subunit in an automated biopolymer synthesis operation.

Growing community of inventors

San Carlos, CA, United States of America

Robert J DeFranco