Abt Holding Company

Oregon Health & Science University

Athersys, Inc.

Rubius Therapeutics, Inc.

Katholieke Universiteit Leuven

Augusta University Research Institute, Inc.

Other

Houston Methodist Hospital

Osiris Therapeutics, Inc.

Medical College of Georgia Research Institute, Inc.

Robert J Deans

Philip R Streeter

Wouter Van't Hof

Magdalena Kovacsovics

Richard Maziarz

Noubar Boghos Afeyan

Avak Kahvejian

Jordi Mata-Fink

John Round

Sivan Elloul

Tom Wickham

Tiffany F Chen

Torben Straight Nissen

Nathan Dowden

Robert W Mays

Saverio La Francesca

Cesar V Borlongan

David C Hess

Aernout Luttun

Anthony E Ting

James E Carroll

David Jordan Fink

Annemarie Moseley

J Mary Murphy

Saverio LaFrancesca

Anthony P Ting

Francis P Barry

The invention relates to the treatment of various injuries, disorders, dysfunctions, diseases, and the like with MAPCs, without the need for adjunctive immunosuppressive treatment.

MAPC therapeutics without adjunctive immunosuppressive treatment

The present invention provides a method for treating wounds by applying cells as described in this application. In one aspect the method provides treatment for cutaneous wounds. In general embodiments the cells are delivered to the wound without being attached to a functionalized substrate in the delivery vehicle.

Stem cells for wound healing

The invention relates to the treatment of various injuries, disorders, dysfunctions, diseases, and the like of the brain with MAPCs, particularly in some aspects, to the treatment of the same resulting from hypoxia, including that caused by systemic hypoxia and that caused by insufficient blood supply. In some further particulars the invention relates, for example, to the treatment of hypoxic ischemic brain injury with MAPCs, in children for example, and to the treatment of cortical infarcts and stroke with MAPCs in adults, for example.

MAPC treatment of brain injuries and diseases

Isolated cells are described that are not embryonic stem cells, not embryonic germ cells, and not germ cells. The cells can differentiate into at least one cell type of each of at least two of the endodermal, ectodermal, and mesodermal lineages. The cells do not provoke a harmful immune response. The cells can modulate immune responses. As an example, the cells can suppress an immune response in a host engendered by allogeneic cells, tissues, and organs. Methods are described for using the cells, by themselves or adjunctively, to treat subjects. For instance, the cells can be used adjunctively for immunosuppression in transplant therapy. Methods for obtaining the cells and compositions for using them also are described.

Immunomodulatory properties of multipotent adult progenitor cells and uses thereof

The invention provides methods and compositions that improve the success of organ transplantation. The methods and compositions are directed to exposing a desired organ to stem cells prior to, during, and/or after transplantation. In one embodiment, the stem cells reduce the deleterious effects of ischemia on an organ designated to be harvested for transplantation or that has been harvested for transplantation. In another embodiment in which an organ designated for transplantation is perfused ex vivo, the method involves reducing ischemic reperfusion injury by perfusing the organ with a medium that contains stem cells.

Organs for transplantation

Immunomodulatory properties of MAPCs and uses thereof

The invention includes compositions and methods related to multimodal therapies, e.g., for treating a cancer. A multimodal therapy described herein provides and/or administers a plurality of agents that function in a coordinated manner to provide a therapeutic benefit to a subject in need thereof, e.g., a subject having a cancer.

Compositions and methods related to multimodal therapeutic cancer indications

Compositions and methods related to engineered erythroid cells comprising IL-15

Methods related to engineered erythoid cells comprising 4-1BBL

Compositions and methods related to engineered erythoid cells comprising 4-1BBL

Growing community of inventors

Riverside, CA, United States of America

Robert J Deans