Hoechst Roussel Pharmaceuticals

Hoechst Marion Roussel

Robert J Cherill

Raymond W Kosley, Jr

Gerard J O'Malley

Novel carbamoyloxylabdanes, intermediates and processes for the preparation thereof, and methods for reducing intraocular pressure and treating cardiac failure utilizing compounds and compositions thereof are disclosed.

Carbamoyloxylabdanes

Carbamoyloxlabdanes

Carbamoyloxylabdane compounds

Novel labdanes, intermediates and processes for the preparation thereof, and methods for reducing intraocular pressure utilizing compounds or compositions thereof are disclosed.

Labdane process

Labdane compounds, pharmaceutical compositions and use

Carbamoyloxylabdane compounds useful in reducing intraocular pressure

Labdanes, pharmaceutical compositions, and their use

Labdanes, pharmaceutical compositions and use

Spiro[2H-1,4-benzodioxepin-3(5H)4'-piperidine and -3-pyrrolidine] compounds of the formula ##STR1## where the substituents are as defined herein, are useful in the treatment of hypertension in mammals. Such compounds, their use as antihypertensive agents, pharmaceutical compositions containing the compounds, intermediates and processes for preparing the compounds are provided.

Intermediates for spiro[2H-1,4 benzodioxepin-3(5H)4'-piperidine and

Novel aminoacyllabdanes, intermediates and processes for the preparation thereof, and methods for reducing intraocular pressure utilizing compounds or compositions thereof are disclosed.

Aminoacyllabdanes

Process for preparing aminoacyllabdanes

Intermediates for spiro[2H-1,4-benzodioxepin-3(5H)4'piperidine and

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Somerset, NJ, United States of America

Robert J Cherill