Ortho Pharmaceutical Corporation

Discovery Laboratories, Inc.

Robert J Capetola

John L McGuire

Albert M Kligman

James A Mezick

Thomas Hofmann

Marvin E Rosenthale

Robert Segal

Mark E Johnson

Methods and compositions to enhance mucus clearance and to treat pulmonary lung disorders such as cystic fibrosis are disclosed. The methods utilize compositions including synthetic pulmonary surfactants having one or more phospholipids and a synthetic polypeptide, administered alone or combined with hyperosmotic agents, to patients in an amount effective to enhance mucus clearance.

Pulmonary surfactant formulations and methods for promoting mucus clearance

The present invention is directed to the topical administration of a retinoid-containing pharmaceutical composition for reversing the effects of glucocorticoid-induced skin atrophy.

Reversal of glucocorticoid-induced skin atrophy

The present invention is directed to the topical administration of a retinoid-containing pharmaceutical composition for the prevention of glucocorticoid-induced skin atrophy.

Prevention of glucocorticoid-induced skin atrophy

A method for treating atopic dermatitis with cyproheptadine or its acid addition salt is described.

Method for treating atopic dermatitis

An analgesic composition comprising a mixture of a centrally-acting analgesic compound and .alpha.-methyl-4-[2-thienylcarbonyl] benzene acetic acid is described. Enhancement of the analgesic effect is observed in the combination.

Analgesic composition

An analgesic composition comprising a mixture of a non-narcotic analgesic compound and L-methyl-4-[2-thienylcarbonyl] benzene acetic acid is described. Potentiation of the analgesic effect is observed in the combination.

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Doylestown, PA, United States of America

Robert J Capetola