University of Connecticut

Robert J Binder

Pramod K Srivastava

The present invention relates to the use of alpha (2) macroglobulin complexes isolated from the serum of a mammal. The invention also relates to methods for making such complexes and compositions comprising alpha (2) macroglobulin complexes, isolated from the serum of a mammal, wherein such compositions are used in methods for the treatment and prevention of cancer and infectious disease. The invention also relates to methods for treating and preventing cancer and infectious disease using such complexes comprising, isolated from the serum of a mammal. The invention also encompasses methods for production of alpha (2) macroglobulin complexes.

Methods and compositions for the treatment of cancer and infectious disease using alpha(2) macroglobulin-antigenic molecule complexes

Methods and compositions for the treatment of cancer and infectious disease using alpha (2) macroglobulin-antigenic molecule complexes

The present invention relates to complexes of alpha (2) macroglobulin associated with antigenic molecules for use in immunotherapy. The invention relates to methods for using such compositions in the diagnosis and treatment of immune disorders, proliferative disorders, and infectious diseases.

Complexes of alpha (2) macroglobulin and antigenic molecules for immunotherapy

The present invention relates to the use of alpha (2) macroglobulin ('&#x3b1;2M') receptor as a heat shock protein receptor, cells that express the &#x3b1;2M receptor bound to an HSP, and antibodies and other molecules that bind the &#x3b1;2M receptor-HSP complex. The invention also relates to screening assays to identify compounds that modulate the interaction of an HSP with the &#x3b1;2M receptor, and methods for using compositions comprising &#x3b1;2M-receptor sequences for the diagnosis and treatment of immune disorders, proliferative disorders, and infectious diseases.

Alpha(2) macroglobulin receptor as a heat shock protein receptor and uses thereof

The present invention relates to the use of alpha (2) macroglobulin ('&#x3b1;2M') receptor as a heat shock protein receptor, cells that express the &#x3b1;2M receptor bound to an HSP, and antibodies and other molecules that bind the &#x3b1;2M receptor-HSP complex. The invention also relates to screening assays to identify compounds that interact with the &#x3b1;2M receptor, and modulate the interaction of the &#x3b1;2M receptor with its ligand, such as HSPs, and methods for using compositions comprising &#x3b1;2M-receptor sequences for the diagnosis and treatment of immune disorders, proliferative disorders, and infectious diseases.

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Farmington, CT, United States of America

Robert J Binder