Randox Laboratories Limited

Randox :Abpratproes :O, Oted

Robert Ivan McConnell

Stephen Peter Fitzgerald

John Victor Lamont

Elouard Benchikh

El Ouard Benchikh

Philip Andrew Lowry

Andrew Philip Lowry

James Rudolf Meyer

Bailin Cao

Ahti Kalevi Kansanaho

Mark Tweedie

Maria Luz Rodriguez

The present invention provides an immunoassay method for detecting or determining the amount of salvinorin A, salvinorin B and/or analogues thereof in an in vitro sample, an antibody for salvinorin A, salvinorin B and/or analogues thereof and a kit for detecting the presence of or determining the amount of salvinorin A, salvinorin B and its analogues thereof in a sample. 

Salvinorin immunoassay

The immunoassay method and kit are provided for the detection and/or the determination of zolpidem. The disclosure provides novel antibodies, derived from a novel immunogen, that are highly sensitive and bind to zolpidem and its main urinary metabolite [3-(2-N,N-dimethylamino-2-oxoethyl)-6-methylimidazo[1,2-a]pyridin-2-yl]benzoic acid, enabling an extension of the detection window of zolpidem in individuals who have abused the drug, or have been victim of its side-effects or its criminal misuse.

Immunoassay with extended detection window

An assay for measuring the amount of a first analyte in a sample, comprises the steps of: (i) contacting the sample with a device that comprises one or more first reaction sites which comprise a first ligand having affinity for the first analyte, and a series of second reaction sites each comprising different known concentrations of an immobilized second analyte; (ii) removing any unbound first analyte; (iii) contacting the device with a second ligand that is detectably labelled and which has affinity for the first analyte, and a third ligand that is detectably labelled and which has affinity for the second analyte; (iv) removing any unbound second and third ligands; and (v) measuring the amount of second and third ligands, wherein measurement of the third ligand is used to establish a calibration curve, used to determine the amount of first analyte present in sample.

Calibrating microarrays

A method of monitoring the properties of a biological or chemical sample. The method includes carrying out a plurality of different tests on the sample to generate corresponding test data; optionally carrying out a preliminary processing of the test data to generate partially processed data; storing the test data and/or partially processed data; causing a processing system to analyze a user-defined selection of the test data or partially processed data to generate result data relating to one or more properties of the sample; and subsequent to the previous step, receiving a second user defined selection of the test data or partially processed data, different from the first selection, and causing the processing system to analyze the second user-defined selection of the test data or partially processed data to generate second result data relating to one or more properties of the sample different from the properties corresponding to the first user-defined selection.

Method and apparatus for monitoring the properties of a biological or chemical sample

The invention provides haptens, immunogens comprising such haptens coupled to an antigenicity-conferring carrier material, conjugates comprising such haptens bonded to a labelling agent as well as, antibodies raised against such immunogens and capable of binding with ketamine and its primary metabolite, norketamine.

Haptens, immunogens, antibodies and conjugates to ketamine and its metabolites

The invention provides a hapten, an immunogen comprising the hapten coupled to an antigenicity-conferring carrier material, a conjugate comprising the hapten coupled to a labelling agent, as well as, antibodies raised against the aforementioned immunogen and capable of binding with MDMA.

Method and kit for detecting, or determining, 3,4-methylenedioxymethamphetamine

The present invention relates to a method for preparing haptens of formulae I and II that are useful in the preparation of immunogens, antibodies and conjugates, for use in competitive immunoassays for the detection of ractopamine, isoxsuprine and ritodrine. The haptens are prepared by reacting a phenylethanolamine derivative of formula D with a phenylalkylcarbonyl derivative of formula E: in which, in formula I, Zis a crosslinker and Zis H and, in formula II, Zis H and Zis a crosslinker.

Phenethanolamine-derived haptens, immunogens, antibodies and conjugates

The invention provides a hapten derivatized with a crosslinker at the nitrogen of the 8&#x3b2;-carboxamide of 2-oxo-3-hydroxy LSD. The invention also provides an immunogen comprising the aforementioned hapten coupled to an antigenicity-conferring carrier material; a conjugate comprising the aforementioned hapten coupled to a labelling agent, as well as, antibodies raised against the aforementioned immunogen and capable of binding with at least the 3-hydroxy-2-pyrrolidone structural epitope of 2-oxo-3-hydroxy LSD.

Haptens, immunogens, antibodies and conjugates to 2-oxo-3-hydroxy-LSD

The invention provides an immunogen comprising a hapten coupled to an antigenicity-conferring carrier material, a conjugate comprising the aforementioned hapten coupled to a labelling agent, as well as, antibodies raised against the aforementioned immunogen and capable of binding with at least one structural epitope of metabolites of fentanyl and of metabolites of fentanyl analogs.

Method and kit for detecting, or determining the quantity of, metabolites of fentanyl and metabolites of fentanyl analogs

Novel haptens, which can be conjugated to form immunogens, are of formula I, II or IIIwherein R is a divalent alkyl, cycloalkyl or aryl group having 1 to 10 carbon atoms, and X is a functional group.

Haptens, immunogens and antibodies to oxycodone and its metabolites

The invention provides a hapten comprising a 6-[D-&#x3b1;-aminoacetamido] penicillin derivative crosslinked at the &#x3b1;-amino group with a substituted or unsubstituted phenyldicarbaldehyde. In addition, the invention provides an immunogen comprising the aforementioned hapten coupled to an antigenicity-conferring carrier material, a conjugate comprising the aforementioned hapten coupled to a labelling agent, as well as, antibodies raised against the aforementioned immunogen and capable of binding with at least one structural epitope of an intact &#x3b2;-lactam ring.

Method and kit for detecting, or determining the quantity of, beta-lactam penicillins

A biochip deposition system and method. The system comprises a deposit mechanism for depositing organic material in spots on a substrate; and a viewing system for detecting the spots on the substrate during a deposit operation and before the spots have dried, for determining if the spots have been correctly deposited, and if not, for generating a suitable output signal. The viewing system includes an illumination device for illuminating deposited spots at a relatively low angle relative to the substrate.

Biochip deposition system and method

A method for imaging molecules contained in an array of discrete reaction sites on the surface of a solid support comprises:

Array imaging method

An assay device incubator comprises a housing () defining a region within which at least one assay device is located in use, the housing defining laterally opposed sidewalls () of at least one bay () in which an assay device can be located. The housing () includes one or more guides () for supporting the assay device and enabling the assay device to undergo to and fro movement therealong. A vibration system () is coupled to the at least one tray in use for vibrating the tray to and fro along the or each guide. A heating system () heats the region within the housing.

Assay device incubator

An assay device processing instrument comprises a plurality of processing modules. A transport system transports an assay device to each processing module, the transport system being adapted to transfer the assay device from the transport system to the module to enable the transport system to transport another assay device while the first is processed by the processing module. A control system controls operation of the transport system such that each assay device is transferred between the modules in a predetermined sequence, and such that a number of assay devices can be processed in different modules simultaneously.

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Ballymena, United Kingdom

Robert Ivan McConnell