Advanced Research & Technology Institute

Robert Hromas

Hal E Broxmeyer

Darron R Brown

Kenneth H Fife

Michell D Krathwohl

The inventors have cloned and expressed the chemokine-like genes from MCV type 1 and the closely related MCV type 2 in order to determine a potential role for these proteins in the viral life cycle. These are the first viral chemokines that have been shown to antagonize the chemotactic activity of human chemokines and the first viral chemokines that have been shown to have inhibitory activity on human hematopoietic progenitor cells. Methods and compositions for exploiting these proteins are disclosed herein.

Functional characterization of the C-C chemokine-like molecules encoded by molluscum contagiosum virus types 1 and 2

The present invention provides purified and isolated chemokine protein, fragments and polypeptide analogs thereof, antibodies thereto, and materials and methods for the recombinant production thereof. These products are useful in therapeutics, such as the treatment of myeloproliferative diseases, as well as in diagnostic and medical imaging applications.

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Indianapolis, IN, United States of America

Robert Hromas