Ligand Pharmaceuticals, Inc.

Rqx Pharmaceuticals, Inc.

Genentech, Inc.

Rempex Pharmaceuticals, Inc.

Prometheus Biosciences, Inc.

Robert Higuchi

Lin Zhi

Peter Andrew Smith

Tucker Curran Roberts

Prasuna Paraselli

David Alan Campbell

Cornelis Arjan Van Oeveren

James Patrick Edwards

Donald Karanewsky

Thomas Lot Stevens Lau

Todd Kevin Jones

Lawrence G Hamann

Brian Walter Eastman

Jacob Bradley Schwarz

Tomasz W Glinka

Olga Rodny

James John Crawford

Cuong Q Ly

Michael F T Koehler

Huiyong Hu

Mark E Adams

Jyun-Hung Chen

Thomas R Caferro

David Mark Wallace

Scott J Hecker

Barbara A Pio

Neelakandha S Mani

Chi Ching Mak

Gavin C Hirst

Keith A Bostian

Sergio G Duron

Yan Liu

Philippe Bergeron

Yongsheng Chen

Anthony W Thompson

Zhiyong Yu

Kristen Lee Arienti

Marquis L Cummings

Charlotte L F Deckhut

Penghui Chen

Mani Neelakandha

Chun Chow

Described herein are GPR35 modulators and methods of using these compounds in the treatment of diseases, disorders or conditions. Also described herein are pharmaceutical compositions containing such compounds.

GPR35 modulators

Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.

Macrocyclic broad spectrum antibiotics

Provided herein are analogs of the natural product arylomycin for the treatment of microbial infections. In some embodiments, the compounds described herein have broad spectrum bioactivity. The compounds provided herein can in other embodiments overcome the resistance conferred by single amino acid mutations at defined positions of bacterial Signal Peptidases (SPases) and in other embodiments provide for a broader spectrum of antibiotic bioactivity compared to the natural product. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.

Broad spectrum antibiotics

Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. The compounds provided herein can in other embodiments overcome the resistance conferred by single amino acid mutations at defined positions of bacterial Signal Peptidases (SPases) and in other embodiments provide for a broad spectrum of antibiotic bioactivity. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.

Linear peptide antibiotics

Provided herein are compounds having a structure selected from among Formula (I), Formula (II), Formula (III), Formula (IV), Formula (V) and Formula (VI) that are androgen receptor modulators and/or androgen receptor binding agents. Also disclosed are methods of making and using such compounds, including, but not limited to, using such compounds for treating various conditions. 

Androgen receptor modulator compounds and methods

Disclosed herein are polybasic bacterial efflux pump inhibitors containing boronic acid functionality and their methods of synthesis, methods of use, and pharmaceutical compositions. Some embodiments include methods of treating or preventing a bacterial infection by co-administering to a subject infected with bacteria or at risk of infection with bacteria the efflux pump inhibitor with another anti-bacterial agent.

Boron containing polybasic bacterial efflux pump inhibitors and therapeutic uses thereof

Disclosed are compounds having polybasic functionalities. The compounds inhibit bacterial efflux pump inhibitors and are used in combination with an anti-bacterial agent to treat or prevent bacterial infections. These combinations can be effective against bacterial infections that have developed resistance to anti-bacterial agents through an efflux pump mechanism.

Polybasic bacterial efflux pump inhibitors and therapeutic uses thereof

This invention relates to compounds that bind to mineralocorticoid receptors and/or modulate activity of mineralocorticoid receptors, and to methods for making and using such compounds. Some embodiments relate to compounds of Formula I: or a pharmaceutically acceptable salt, ester, amide, or prodrug thereof, wherein R&#x2014;Rare as defined herein.

Mineralocorticoid receptor modulator compounds, processes for their preparation, and their uses

This invention relates to compounds that bind to mineralocorticoid receptors and/or modulate activity of mineralocorticoid receptors, and to methods for making and using such compounds. Some embodiments relate to compounds of Formula I: 

Mineralocorticoid receptor modulator compounds and methods, and pharmaceutical compositions containing these compounds

Growing community of inventors

Solana Beach, CA, United States of America

Robert Higuchi