Transmedics, Inc.

Robert Havener

Waleed H Hassanein

Richard Bringham

Tamer I Khayal

Ihab Abdel Fattah

Stanley Kyi

Anas Abdelazim

Scott W Newell

John Sullivan

Robert Fishman

Mark Anderson

Matthew De Remer

Michael Van Driel

Paul Murray

Doug Harriott

Ron Taylor

Ahmed Elbetanony

Vincent Lambert, Ii

Burt Ochs

Tom Bishop

Thomas H Bishop

Hesham Saleh

Jon C Trachtenberg

Ronald Taylor

Paul Lezberg

Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.

Systems and methods for ex vivo lung care

The disclosure provides for electrode systems and perfusion systems that may be configured to measure the electrical activity of an explanted heart and to provide defibrillation energy as necessary. The perfusion systems may maintain the heart in a beating state at, or near, normal physiological conditions; circulate oxygenated, nutrient enriched perfusion fluid to the heart at or near physiological temperature, pressure, and/or flow rate. These systems may include a pair of electrodes that may be placed epicardially on the right atrium and/or left ventricle of the explanted heart, and/or an electrode placed in the aortic blood path.

Systems for monitoring and applying electrical currents in an organ perfusion system

Electrode systems have been developed for use in perfusion systems to measure the electrical activity of an explanted heart and to provide defibrillation energy as necessary. The perfusion systems maintain the heart in a beating state at, or near, normal physiological conditions; circulating oxygenated, nutrient enriched perfusion fluid to the heart at or near physiological temperature, pressure and flow rate. These systems include a pair of electrodes that are placed epicardially on the right atrium and left ventricle of the explanted heart, as well as an electrode placed in the aortic blood path.

An ex-vivo lung solution for machine perfusion of donor lungs on OCS. The solution may be mixed with whole blood or packed red blood cells to form the OCS lung perfusion solution.

Organ care solution for ex-vivo machine perfusion of donor lungs

Electrode systems have been developed for use in perfusion systems to measure the electrical activity of an explanted heart and to provide defibrillation energy as necessary. The perfusion systems maintain the heart in a heating state at, or near, normal physiological conditions; circulating oxygenated, nutrient enriched perfusion fluid to the heart at or near physiological temperature, pressure and flow rate. These systems include a pair of electrodes that are placed epicardially on the right atrium and left ventricle of the explanted heart, as well as an electrode placed in the aortic blood path.

The invention, in various embodiments, provides systems, methods and solutions for perfusing an organ ex vivo.

Systems and methods for ex vivo organ care

The invention, in various embodiments, provides systems, methods and solutions using an organ ex vivo.

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Lynnfield, MA, United States of America

Robert Havener