The United States of America, As Represented by the Secretary, Department of Health and Human Services

USA As Represented by Secretary of the Navy

The United States of America As Represented by the Department of Health

Mriglobal

Provid Pharmaceuticals Inc.

Glg Pharma, LLC

Robert H Shoemaker

Michael R Boyd

Kirk R Gustafson

James Brislin McMahon

Michael Currens

Yves Pommier

John Cardellina

Dominic Scudiero

Christopher Self

Guangtao Zhang

Andrew Jobson

George Lountos

David Waugh

Charles Michael Cook

Louis E Henderson

Shanker Gupta

Robert J Fisher

Alan Rein

Andrew Vargha Colasanti

Hang Yuan, Legal Representative

Andrew Stephen

Karen Worthy

Michael W Lovell

Shizuko Sei

Bruce Crise

Jonathan M White

Sudhir Kondapaka

Andy Jobson

John Cardelina

Disclosed is a salt prepared from the STAT3 inhibitor known as 2-hydroxy-4-[[2-[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino] benzoic acid and 2-amino-2-(hydroxymethyl)-1,3-propanediol. The salt is soluble in water and stable for extended periods of time. Further provided are pharmaceutical compositions comprising the salt and methods of administering the salt to prevent and treat cancer, such as breast cancer.

STAT3 inhibitor formulation

A method of treating an Hepatitis C Virus infection in a patient, comprising providing a therapeutically effective amount, to a patient in need thereof, of a compound of Formula (I) or a pharmaceutically acceptable salt thereof, wherein: Gis a group of the formula or where n is 0, 1, 2, 3, or 4 and Het is a 5- or 6-membered heteroaryl group containing 1 to 4 heteroatoms independently chosen from N, O, and S, which Het is optionally substituted. 

Method of treating HCV infection with a small molecule CHK2 inhibitor

Described herein are Chk2-inhibitor compounds and derivatives thereof, and methods of treating or preventing disease and disease symptoms using the compounds and compositions thereof.

Use of Chk2 kinase inhibitors for cancer treatment

Provided herein are Compounds having the following structure: 

Kinase inhibitors, compositions thereof, and methods of use therewith

The invention provides methods and pharmaceutical compositions for inhibiting viral replication, particularly retroviral replication. The methods comprise administration of stibonic acid or diphenyl compounds that disrupt viral nucleocapsid binding to nucleic acids.

Identification of anti-HIV compounds inhibiting virus assembly and binding of nucleocapsid protein to nucleic acid

The present invention provides antiviral proteins (collectively referred to as cyanovirins), conjugates thereof, DNA sequences encoding such agents, host cells containing such DNA sequences, antibodies directed to such agents, compositions comprising such agents, and methods of obtaining and using such agents.

Antiviral proteins and peptides, DNA coding sequences therefor, and uses thereof

The present invention provides antiviral proteins, peptides and conjugates, as well as methods of obtaining these agents. The antiviral proteins, peptides and conjugates of the present invention can be used alone or in combination with other antiviral agents in compositions, such as pharmaceutical compositions, to inhibit the infectivity, replication and cytopathic effects of a virus, such as a retrovirus, in particular a human immunodeficiency virus, specifically HIV-1 or HIV-2, in the treatment or prevention of viral infection.

Conjugates of antiviral proteins or peptides and virus or viral envelope glycoproteins

The present invention provides antiviral proteins (collectively referred to as cyanovirins), conjugates thereof, DNA sequences ending such agents, host cells containing such DNA sequences, antibodies directed to such agents, compositions comprising such agents, and methods of obtaining and using such agents.

Anti-cyanovirin antibody

Nucleic acids encoding antiviral proteins and peptides fused to effector

Antiviral proteins and peptides

Nucleic acids encoding antiviral proteins and peptides, vectors and host

Growing community of inventors

Boyds, MD, United States of America

Robert H Shoemaker