Janssen Pharmaceutica Nv

Ortho-Mcneil Pharmaceutical Corp.

Robert H Gruninger

Peter J Connolly

Stuart Emanuel

Ronghui Lin

Steven A Middleton

Steven K Wetter

Shenlin Huang

Yanhua Lu

1,2,4-Triazolylaminoaryl(heteroaryl)sulfonamide derivatives of formula (I), pharmaceutically acceptable salts thereof, processes for the manufacture of 1,2,4-triazolylaminoaryl(heteroaryl)sulfonamide derivatives and pharmaceutical compositions containing 1,2,4-triazolylaminoaryl(heteroaryl)sulfonamide derivatives are disclosed:  The 1,2,4-triazolylaminoaryl(heteroaryl)sulfonamide derivatives of formula (I) possess cell cycle inhibitory activity and are accordingly useful for their anti cell proliferation (such as anti cancer) activity.

1,2,4-triazolylaminoaryl (heteroaryl) sulfonamide derivatives

1,2,4-Triazolylaminoaryl (heteroaryl) sulfonamide derivatives

The present invention provides substituted triazole diamine derivatives as selective kinase or dual-kinase inhibitors and a method for treating or ameliorating a selective kinase or dual-kinase mediated disorder.

Substituted triazole diamine derivatives as kinase inhibitors

The present invention provides amino substituted pyridinyl methanone compounds; pharmaceutical compositions comprising the compounds and methods of synthesis thereof. The compounds, which are cyclin dependent kinase (CDK) inhibitors, can be used to treat or ameliorate CDK mediated disorders. The invention thus also provides the therapeutic or prophylactic use of the compounds and/or pharmaceutical compositions to treat such disorders.

Amino substituted pyridinyl methanone compounds useful in treating kinase disorders

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Easton, PA, United States of America

Robert H Gruninger