California Institute of Technology

University of California

Other

United States of America As Represented by the Secretary of the Air Force

University of Southern California

Honda Motor Co., Ltd.

Materia, Inc.

Calhoun Vision, Inc.

Rxsight, Inc.

Umicore Ag & Co. Kg

Children's Hospital of Los Angeles

The United States Government As Represented by the Department of Veterans Affairs

Pharmacopeia Inc.

Cornell University

Bend Research, Inc.

Robert H Grubbs

Anton A Toutov

Kerry N Betz

Brian M Stoltz

Daniel M Schwartz

Alexey Fedorov

Julia A Kornfield

Raymond Weitekamp

Wenbo Liu

Simon Christopher Jones

Christian A Sandstedt

Jagdish M Jethmalani

Mark Salman Humayun

Peter Schwab

SonBinh T Nguyen

Thomas F Miller, Iii

Sonbinh T Nguyen

Nathan S Lewis

Richard L Pederson

Harry B Gray

Rusty Lew Blanski

Christopher M Bates

Victoria K Davis

John P Morgan

Tonia S Ahmed

Thomas E Wilhelm

Nebojsa Momcilovic

Christopher J Brooks

Marshall Leedy Stoller

Hoyong Chung

Shiao H Chang

Choon Woo Lee

Charles S Woodson

Garret M Miyake

Victoria Piunova

Brett M Savoie

Michael A Webb

Vanessa M Marx

Kaoru Omichi

Jennifer Marie Murphy

Carl M Blumenfeld

Yu-Chong Tai

Lynda Kaye Johnson

Thomas W Kenny

Ashish Ahuja

Yann Schrodi

Bruce M Novak

Adam M Johns

Jason Lee Moore

David R Hinton

Lincoln Vallance Johnson

Sherry T Hikita

Dennis A Dougherty

Alissa M Fitzgerald

Harry A Atwater

Scott E Fraser

David M Lynn

Rodney M Goodman

Qingmin Xu

William Wolf

Takeharu Morita

Alice Chang

Bob R Maughon

Christopher Scot Daeffler

Dennis O Clegg

Bryan A Fiamengo

Mark Edward Thompson

Mark S Trimmer

Arnab Kumar Chatterjee

Changjun Yu

David A Tirrell

Axel Brait

Andrew Jackson Boydston

Hyuck Choo

Jacob Berlin

Nam Hawn Chou

F Dean Toste

Melanie S Sanford

Gregory L Kirk

Robert Dean Sanner

Geoffrey William Coates

Andrew Bell

Eric A Pape

Thomas P Russell

Marc Andrew Hillmyer

Thomas Jon Seiders

Patrick Case

Azita Emami

Michael Richard Harrison

Daniel J Laser

Julia Rosolovsky Greer

Guy Bertrand

Scott C Virgil

Ryan K McKenney

Chen Xu

Sung Woo Hong

Cheol Keun Chung

Slobodan Mitrovic

Robert E Maloney

Ryan Mckenney

The present disclosure sets forth novel compounds and compositions including heteroaromatic silicon-fluoride-acceptors, which are useful for PET scanning. The present disclosure further includes novel methods ofF imaging for PET scanning, the methods comprising the preparation of conjugates and bioconjugates of biological ligands of interest with heteroaromatic silicon-fluoride-acceptors. In certain embodiments the invention is practiced in the form of a kit.

Heteroaromatic silicon-fluoride-acceptors useful forF labeling of molecules and biomolecules, and methods of preparing same

Aspects disclosed herein include a system for generating singlet oxygen in a gas, the system comprising: a substrate; and hexanuclear clusters operably immobilized on at least a portion of the substrate; wherein each hexanuclear cluster comprises a photosensitive octahedral core complex characterized by formula FX1a: MX(FX1a); wherein each M is independently Mo, W, or Re; wherein each X is independently a halide anion ligand; wherein the clusters are exposed to the gas and the gas comprises Ogas; wherein the clusters are exposed to a light; and wherein each hexanuclear cluster is a photosensitizer configured to generate the gaseous singlet oxygen when irradiated by the light in the presence of the Ogas.

Photocatalytic generation of singlet oxygen for air purification

The present disclosure relates to fluoride ion batteries and structures of metal based electrode materials for various fluoride ion batteries. The structures of the metal based electrode materials comprise one or more shells or interfaces, enabling the electrodes to operate at room temperature with a liquid electrolyte.

Liquid-type room-temperature fluoride ion batteries

A dual-flange stent can have a therapeutic effect that can bring about a marked increase in patency. The dual flanges of the stent can comprise a first discrete flange component and a second discrete flange component. One or both flange components can include a magnetic element. The stent can further comprise a shaft connecting the flange components. At least one of the flanges can transition between a first configuration and a second configuration, where the first configuration is compact and the second configuration provides a large tissue-compressing surface. In one instance, the transition to the configuration with a large tissue-compressing surface can include filling a balloon with saline or another fluid. The first flange and the second flange may be drawn together to compress interposed tissue of the stricture.

Expanding devices for endoluminal interventions

This invention relates generally to the synthesis of Δ-Prostaglandin J product using stereoretentive ruthenium olefin metathesis catalysts supported by dithiolate ligands. Δ-Prostaglandin J products were generated with excellent selectivity (>99% Z) and in moderate to high/good yields (47% to 80% yield; 58% to 80% yield).

Total synthesis of prostaglandin J natural products by stereoretentive metathesis

A surgical method of cataract fragmentation and extraction via microbubble cavitation is described. In particular, gas-filled microbubbles are injected into a lens capsule of a subject's eye, and cavitation of the microbubbles is activated by applied ultrasound energy. The ultrasound energy can be applied from an external device. The cavitation fragments cataract tissues without damaging other tissue, such as the lens capsule. Fragmented lens material is then aspirated from the lens capsule. The method can be used alone or in conjunction with other methods, such as phacoemulsification.

Method for eye lens removal using cavitating microbubbles

Electrolyte solutions including at least one anhydrous fluoride salt and at least one non-aqueous solvent are presented. The fluoride salt includes an organic cation having a charge center (e.g., N, P, S, or O) that does not possess a carbon in the &#x3b2;-position or does not possess a carbon in the &#x3b2;-position having a bound hydrogen. This salt structure facilitates its ability to be made anhydrous without decomposition. Example anhydrous fluoride salts include (2,2-dimethylpropyl)trimethylammonium fluoride and bis(2,2-dimethylpropyl)dimethylammonium fluoride. Combining these fluoride salts with at least one fluorine-containing non-aqueous solvent (e.g., bis(2,2,2-trifluoroethyl)ether; (BTFE)) promotes solubility of the salt within the non-aqueous solvents. The solvent may be a mixture of at least one non-aqueous, fluorine-containing solvent and at least one other non-aqueous, fluorine or non-fluorine containing solvent (e.g., BTFE and propionitrile or dimethoxyethane). The electrolyte solutions may be employed in electrochemical cells, such as batteries, fuel cells, electrolysis systems, and capacitors.

Non-aqueous fluoride salts, solutions, and their uses

A highly efficient, Z-selective ring-closing metathesis system for the formation of macrocycles using a stereoretentive, ruthenium-based catalyst supported by a dithiolate ligand is reported. This catalyst is demonstrated to be remarkably active as observed in initiation experiments showing complete catalyst initiation at &#x2212;20&#xb0; C. within 10 min. Using easily accessible diene starting materials bearing a Z-olefin moiety, macrocyclization reactions generated products with significantly higher Z-selectivity in appreciably shorter reaction times, in higher yield, and with much lower catalyst loadings than in previously reported systems. Macrocyclic lactones ranging in size from twelve-membered to seventeen-membered rings are synthesized in moderate to high yields (68-79% yield) with excellent Z-selectivity (95%-99% Z).

Highly efficient synthesis of Z-macrocycles using stereoretentive, ruthenium-based metathesis catalysts

This invention relates generally to olefin metathesis catalyst compounds, to the preparation of such compounds, compositions comprising such compounds, methods of using such compounds, articles of manufacture comprising such compounds, and the use of such compounds in the metathesis of olefins and olefin compounds. The invention has utility in the fields of catalysts, organic synthesis, polymer chemistry, and industrial and fine chemicals industry.

Synthesis and characterization of Ru alkylidene complexes

The present disclosure is directed to hydrosilyl amines and fluorosilyl amines and methods of making the same.

Hydrosilylamines and fluorosilylamines and methods of making the same

The present disclosure describes methods for silylating aromatic derivatives, comprising the use of hydrosilanes and potassium hydroxide.

Silylated derivatives of aromatic heterocycles

This invention related to manufactured microbubbles, as well as methods of using manufactured microbubbles, for example, in medicinal applications. The invention pertains to the physical structure and materials of the microbubbles, as well as to methods for manufacturing microbubbles, methods for targeting microbubbles for specific medicinal applications, and methods for delivering microbubbles in medical treatment.

Targeting microbubbles

The present disclosure is directed to fluoride (F) ion batteries and F shuttle batteries comprising an anode with a solid electrolyte interphase (SEI) layer, a cathode comprising a core shell structure, and a liquid fluoride battery electrolyte. According to some aspects, the components therein enable discharge and recharge at room-temperature.

Solid electrolyte interphase (SEI) application on anode of fluoride ion/shuttle batteries

The present disclosure is directed to fatty-acid glycerol ester derivative compounds containing a targeting bisphosphonate group. The disclosure further includes pharmaceutical or biomedical compositions comprising these compounds, and methods of using these compounds and compositions forming microbubbles. The microbubbles have affinity for metal-containing, especially calcium-containing, bodies and/or biological targets. In certain embodiments, these compositions are useful for providing targeted placement of microbubbles capable of cavitation on application of high frequency energy.

Synthesis and application of microbubble-forming compounds

Growing community of inventors

South Pasadena, CA, United States of America

Robert H Grubbs