Ortho Pharmaceutical Corporation

Ortho-mcneil Pharmaceutical Corp.

The Scripps Research Institute

Other

Scripps Clinic and Research Foundation

Robert H Chen

Min Amy Xiang

Allen B Reitz

Michael P Wachter

Ramesh M Kanojia

Michael G Goodman

Peter J Connolly

David Anthony Demeter

Tina Morgan Ross

Carlos Plata-Salaman

Hoau-Yan Wang

Malcolm K Scott

Daniel H S Lee

Bruce E Maryanoff

Stanley Charles Bell

Roland K Robins

Zoltan G Hajos

Mary Pat Beavers

Ashitosh Swarup

William O Weigle

Michael C Goodman

Jason Lee Speyer

Maud Urbanski

William J Hennen

John Francis Barrett

John B Moore, Jr

A system, processing structure and method for performing vehicle intercept includes target acceleration estimation or blocking via a filter prior to deriving an interceptor acceleration time history via a guidance law. In the processing structure where the unknown target accelerations are blocked from affecting estimates, a guidance law is generated, stored and retrieved accounting for worst case target acceleration. In the processing structure where the target acceleration is presumed constant with a constant bank angle, the guidance law is closed form, exploiting constant heading angular velocity, and thus generated online.

Homing missile guidance and estimation algorithms against advanced maneuvering targets

The invention is directed to a method of treating a neurodegenerative disorder in a subject in need thereof which comprises administering to the subject an amount of a compound effective to inhibit the interaction of amyloid-beta with alpha-7 nicotinic acetylcholine receptors.

Method for treating neurodegenerative disorders

The compounds of formula I are useful in treating gastrointestinal disorders associated with antagonizing the motilin receptor. The compounds compete with erythromycin and motilin for the motilin receptor. In addition the compounds are antagonists of the contractile smooth muscle response to those ligands.

Cyclobutene derivatives useful as antagonists of the motilin receptor

Cyclopentene derivatives useful as antagonists of the motilin receptor

Method of treating neurodegenerative disorders via inhibition of amyloid beta peptide binding

Cyclohexene derivatives useful as antagonists of the motilin receptor

Cyclopentene compounds useful as antagonists of the motilin receptor

Compounds of Formula I ##STR1## wherein, R.sub.1 through R.sub.7 are described herein. These compounds inhibit the production of arachidonic acid products associated with 5-lipoxygenase and cyclooxygenase and are useful in the treatment of inflammatory disorders.

1,5-diarylpyrazoles

The compounds of formula I are useful in treating gastrointestinal disorders associated with antagonizing the motilin receptor disorders. The compounds compete with erythromycin and motilin for the motilin receptor. In addition the compounds are antagonists of the contractile smooth muscle response to those ligands.

Acetylenic 1,5-diarylpyrazoles as antiinflammatory agents

Immunostimulating 7,8-disubstituted guanine derivatives that also contain a 9-alkyl, 9-alkoxy or 9-aralkyl substituent are disclosed whose structures are represented by Formula I ##STR1## wherein X is O or S; R.sup.1 is a hydrocarbyl or substituted hydrocarbyl group having a length of about one to about seven carbon atoms; R.sup.2 is a hydrocarbyl or hydroxyl- or ether-substituted hydrocarbyl group having a length of about four to about ten carbon atoms; and the pharmaceutically acceptable base addition salts thereof. Also disclosed are compositions containing an immunostimulating guanine derivative and processes for using the same.

N.sup.9 alkyl or aralkyl derivatives of 7, 8-disubstituted guanines

The invention relates to cyclohexenyl antibacterial compounds of the formula I: ##STR1## and pharmaceutical compositions containing the compounds, methods for their production and use.

2-disubstituted cyclohexenyl and cyclohexyl antimicrobial agents

Immunostimulating 7,8-disubstituted guanine derivatives that also contain a .beta.-9,1'-linked-2',3'-dideoxy-2',3'-didehydroribosyl substituent are disclosed whose structures are represented by Formula I ##STR1## wherein X is O or S; R.sup.1 is a hydrocarbyl or substituted hydrocarbyl moiety having a length of about one to about seven carbon atoms; R.sup.2 is hydrogen or C.sub.1 -C.sub.8 acyl; and the pharmaceutically acceptable base addition salts thereof. Also disclosed are compositions containing an immunostimulating guanine derivative and processes for using the same.

2'3'-dideoxy-2',3'-didehydro-7,8-disubstituted guanosines and their

Immunostimulating 7,8-disubstituted guanine derivatives that also contain a morpholinyl group as a position-9 substituent are disclosed whose structures are represented by formula I ##STR1## wherein X is O or S; R.sup.1 is a hydrocarbyl or substituted hydrocarbyl group having a length of about one to about seven carbon atoms; R.sup.2 is a hydrogen or C.sub.1 -C.sub.8 acyl; R.sup.3 is hydrogen, a C.sub.1 -C.sub.5 aliphatic hydrocarbyl, aralkyl or substituted aralkyl group; and the pharmaceutically acceptable base addition salts thereof. Also disclosed are compositions containing an immunostimulating substituted guanine derivative and processes for using the same.

Use of N9 morpholino derivatives of 7,8-disubstituted guanines

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Belle Mead, NJ, United States of America

Robert H Chen