Washington University

Robert H Baloh

Alan Pestronk

Alison M Goate

Nigel J Cairns

Michael A Gitcho

Jeffrey D Milbrandt

The present invention provides nucleic acids and peptides, and methods of using the nucleic acids and peptides to identify subjects at risk for a TDP-43 proteinopathy. The invention also provides for an array comprising the nucleic acids and peptides of the invention.

Sequences associated with TDP-43 proteinopathies and methods of using the same

The present invention provides nucleic acids and peptides, and methods of using the nucleic acids and peptides to identify subjects at risk for a TDP-43 proteinopathy. The invention also provides for an army comprising the nucleic acids and peptides of the invention.

Chimeric GDNF family ligands which activate a GFR&#x3b1;/RET are disclosed. Included are chimeras which activate GFR&#x3b1;1/RET but do not activate GFR&#x3b1;2-RET or GFR&#x3b1;3-RET. The chimeras are useful in providing trophic support to a mammalian cell or in producing differentiation of a mammalian cell, or both, particularly when the cell is in a patient suffering from various diseases, in particular Parkinson's Disease.

GFR&#x3b1;1-RET specific agonists and methods therefor

A novel growth factor, artemin, which belongs to the GDNF/neurturin/persephin family of growth factors, is disclosed. The human and mouse amino sequences have been identified. Human and mouse artemin genomic DNA sequences have been cloned and sequenced and the respective cDNA sequences identified. In addition, methods for treating degenerative conditions using artemin, methods for detecting artemin gene alterations and methods for detecting and monitoring patient levels of artemin are provided.

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St. Louis, MO, United States of America

Robert H Baloh