Georgia Tech Research Corporation

Children's Healthcare of Atlanta, Inc.

Queensland University of Technolgy

Robert Guldberg

Barbara Dale Boyan

Zvi Schwartz

Niren Murthy

Christopher Douglas Hermann

David N Ku

Xinghai Ning

Stephen J Kennedy

David Scott Wilson

Tamim Diab

Andres Jose Garcia

David M Collard

Catherine D Reyes

Timothy Petrie

Jenny E Raynor

Abigail M Wojtowicz

Dietmar W Hutmacher

Yash M Kolambkar

Christopher Vinson Gemmiti

Compositions and methods are described for a polymer hydrogel created by a cycloaddition reaction between an azide and an alkyne that proceeds rapidly without catalyst to produce the polymer hydrogel in less than ninety seconds. The polymer hydrogel can be used in in vivo applications for the localized delivery of therapeutic agent in aqueous solutions. An example of therapeutic delivery of a protein in a mouse model is demonstrated.

Polymer hydrogels for in vivo applications and methods for using and preparing same

Systems and method to affect anatomical structures is disclosed. The systems and method can be used to regenerate bone. The system can comprise a nanofiber mesh configured to substantially conform to an anatomical structure, wherein at least a portion of the nanofiber mesh defines a fillable space. The system can comprise a carrier substance comprising an active agent, such as a bone morphogenetic protein, The carrier substance can be disposed within the fillable space.

Systems and methods to affect anatomical structures

Implantable biomaterials, particularly hydrogel substrates with porous surfaces, and methods for enhancing the compatibility of biomaterials with living tissue, and for causing physical attachment between biomaterials and living tissues are provided. Also provided are implants suitable for load-bearing surfaces in hard tissue repair, replacement, or augmentation, and to methods of their use. One embodiment of the invention relates to an implantable spinal disc prosthesis.

Hydrogel implant with superficial pores

Methods and compositions are provided for improving tissue growth and device integration in vivo. Substrates and devices coated with an &#x3b1;&#x3b2;or &#x3b1;&#x3b2;integrin-specific ligand are provided. The substrates and devices coated with an &#x3b1;&#x3b2;or &#x3b1;&#x3b2;integrin-specific ligand are shown to have greater tissue formation on the surface relative to controls, in particular greater bone formation.

Biomolecular coating for implants

Method of making load bearing hydrogel implants

Load bearing biocompatible device

A bioreactor and methods of using same for making tissue constructs and for conditioning tissue-engineered constructs and harvested tissues such as cryopreserved tissues. The bioreactor allows for static and dynamic culture/conditioning. The bioreactor is dual chambered (one chamber above and one below the cells or construct) to allow for application of biochemical and/or biomechanical stimuli to each side of the cells/construct.

Bioreactor and methods for tissue growth and conditioning

Growing community of inventors

Marietta, GA, United States of America

Robert Guldberg