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Agriculture Victoria Services Pty Limited

Pfizer Products Inc.

Pig Research and Development Corporation

Robert Gerard Ankenbauer

Everett Lee Rosey

Brian T Suiter

Manuel Campos

Robin Lee Keich

Michael Panaccio

Detlef Hasse

Lynn Warren-Stewart

Mary Jo Baarsch

The present invention relates generally to therapeutic compositions for the treatment and/or prophylaxis of intestinal disease conditions in animals and birds caused or exacerbated byor similar or otherwise related microorganism. In particular, the present invention provides a novel gene derived fromwhich encodes an immunogenic hemolysin peptide, polypeptide or protein that is particularly useful as an antigen in vaccine preparation for conferring humoral immunity againstand related pathogens in animal hosts. The present invention is also directed to methods for the treatment and/or prophylaxis of such intestinal disease conditions and to diagnostic agents and procedures for detectingor similar or otherwise related microorganisms.

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The present invention is directed to five novel, low molecular weight proteins from ( ), which are capable of inducing, or contributing to the induction of, a protective immune response in swine against . The present invention is further directed to polynucleotide molecules having nucleotide sequences that encode the proteins, as well as vaccines comprising the proteins or polynucleotide molecules, and methods of making and using the same.

Proteins from actinobacillus pleuropneumoniae

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Pawcatuck, CT, United States of America

Robert Gerard Ankenbauer