Commonwealth Scientific and Industrial Research Organisation

Robert George Whittaker

Veronika Judith Bender

Minoo Jalili Moghaddam

Wayne Gerrard Reilly

Fiona Helen Cameron

Philip Anthony Jennings

Trevor John Lockett

Kenneth Geoffrey Finney

Phillp Anthony Jennings

Wayne Gerard Reilly

Yan Yu

Simon MacEwan Carroll

The present invention provides therapeutic conjugates which comprise a therapeutic compound bound to one to three acyl groups derived from fatty acids. The therapeutic compounds are preferably non-steroidal anti-infiammatory agents which include a carboxylic acid group. The compounds involve the use of tromethamine or ethanolamine derivative to link the acyl groups derived from fatty acids to the therapeutic compounds.

Therapeutic compound-fatty acid conjugates

A therapeutic compound of the chlorambucil family conjugated to two or three acyl groups derived from fatty acids. The compound has the following formula.

Therapeutic compound&mdash;fatty acid conjugates

Self-adjuvanting peptide vaccine delivery system and production thereof

Assay for the detection of proteases

Delivery of nucleic acids

The present invention provides novel compounds in which peptides, amino acids or derivatives thereof are bound to other molecules, in particular fatty acids, which facilitate the use of such peptides, amino acids or derivatives thereof. The basic structure of the compounds of the present invention are an amino acid, peptide or derivative thereof linked to 1 to 3 fatty acid molecules via a tromethamine derivative. Alternatively, the amino acid, peptide or derivative thereof may be linked to a fatty acid by an ethanolamine derivative.

Amino acids peptides or derivatives thereof coupled to fats

The present invention provides a method for introducing nucleic acids into cells. The method involves exposing the cells to a compound having the formula ##STR1## in which: w is a nucleic acid

Composition and method for delivery of nucleic acids

Non-steroidal anti-inflammatory fatty acid conjugates and their

Compounds in which peptides, amino acids, or derivatives of these compounds are conjugated to fatty acids, including ethanolamine and tromethamine. The fatty acids facilitate the therapeutic use of the compounds by enhancing immunogenic properties of the compounds, enhancing absorption of the peptide-fatty acid conjugates and providing slow release delivery of the compounds.

Amino acids, peptides or derivatives thereof coupled to fats

Growing community of inventors

New South Wales, Australia

Robert George Whittaker