US Government As Represented by the Secretary of the Army

USA As Represented by Secretary of the Navy

The Walter Reed Army Institute of Research

U.S. Medical Research Institute of Infectious Diseases

Robert G Ulrich

Sina Bavari

Mark A Olson

Peter M Pushko

Jonathan F Smith

John S Lee

Teddy Kamata

The disclosure relates to compositions, assays, methods and kits comprising one or more amino acid sequences of a filovirus protein, or a fragment thereof, which find use in the detection of a filovirus infection and/or the presence of antibodies specific for a filovirus in a biological sample.

Method and composition for determining specific antibody responses to species of filovirus

The present invention relates to genetically attenuated superantigen toxin vaccines altered such that superantigen attributes are absent, however the superantigen is effectively recognized and an appropriate immune response is produced. The attenuated superantigen toxins are shown to protect animals against challenge with wild type toxin. Methods of producing and using the altered superantigen toxins are described.

Bacterial superantigen vaccines

Altered superantigen toxins

Using nucleic acids encoding mutant SEA and SEB exotoxins from, compositions and methods for use in inducing an immune response which is protective against staphylococcal aureus intoxication in subjects is described.

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Fusion protein of streptococcal pyrogenic exotoxins

Using nucleic acids encoding mutant SEA and SEB exotoxins from , compositions and methods for use in inducing an immune response which is protective against intoxication in subjects is described.

Vaccine against Staphylococcus intoxication

Growing community of inventors

Frederick, MD, United States of America

Robert G Ulrich