Astra Lakemedel Aktiebolag

Zyma Sa

Schering Corporation

Johnson Matthey Public Limited Company

Robert G Tyson

Derek R Palmer

Alban I Albert

Marc E Ballenegger

Andre J Weith

Christian G Rimbault

Dhiru B Vashi

Pierre Courbat

David E Grove

Phillip J Cotterill

Jan C Overeem

David G Thompson

Joseph F Lamendola

David F Booker

This invention relates to a novel process for preparing 3-amino-2-methylbenzotrifluoride from benzotrifluoride. The process comprises nitrating benzotrifluoride to form 3-nitrobenzotrifluoride, reacting this compound with trimethyl sulphoxonium halide to form 3-nitro-2-methylbenzotrifluoride and reducing the nitro group to an amino group.

Synthesis of 3-amino-2-methylbenzotrifluoride

The novel compound .alpha.-bromodiethylcarbonate, novel methods for the preparation thereof, its use in the preparation of 1-ethoxycarbonyloxyethyl esters of penicillins and cephalosporins, and improvements in the method for preparing such esters.

.alpha.-bromodiethylcarbonate

Pharmaceutical preparations containing (+)-cyanidan-3-ol derivatives of the formula I ##STR1## wherein R' and R' are hydrogen, an unsubstituted or substituted hydrocarbon radical, or heterocyclic radical, halogen, formyl, free or functionally modified carboxyl, free or etherified or esterified hydroxyl, free, etherified or oxidized mercapto, unsubstituted or substituted sulfamoyl, acyl or unsubstituted or substituted amino, where however R' and R' cannot both be hydrogen simultaneously, and R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are each hydrogen or an unsubstituted or substituted hydrocarbon radical, and R.sub.2 and R.sub.3 together can also be an unsubstituted or substituted methylene group, and R.sub.1 also an acyl group or an amidated carboxyl group; and therapeutically applicable salts of these compounds, as well as new compounds of these preparations. These pharmaceutical preparations are particularly valuable for treating liver and venous diseases.

Pharmaceutical preparations containing (+)-cyanidan-3-ol derivatives,

Methods for the preparation of .alpha.-bromodiethylcarbonate

Compound of the formula ##STR1## in which R and R' represent hydrogen or an optionally substituted hydrocarbon radical or acyl radical,

(+)-Cyanidan-3-ol derivatives, pharmaceutical preparations that contain

A process for recovering re-usable triarylphosphine (e.g. triphenylphosphine) from rhodium catalyst residues poisoned by the presence of alkyldiarylphosphine (e.g. n-propyldiphenylphosphine) such as are obtained as spent catalyst residues from the hydroformylation of olefins. The process comprises subjecting the poisoned residues to evaporative separation under reduced pressure to separate a vapor comprising triarylphosphine from the rhodium and then mixing the condensed vapor with polar solvent and obtaining the triarylphosphine as a crystalline precipitate from the solvent. The crystalline phosphine is sufficiently free of poisons to be re-usable as a catalyst component in a hydroformylation process.

Process for recovering triarylphosphine from poisoned rhodium catalyst

Growing community of inventors

Prestatyn, United Kingdom

Robert G Tyson