The Rockefeller University

The Rockfeller University

Robert G Roeder

Philip A Cole

Tapas Kumar Kundu

Ehab M Khalil

Joseph D Fondell

Chao Xingyuan

Ontario D Lau

Jack Fred Greenblatt

Hua Xiao

Raymond E Soccio

Vikas B Palhan

Mitsuhiro Ito

Recombinant expression systems for the production of proteins, and particularly a system for rapidly generating recombinant silkworm baculoviruses. nuclear polyhedrosis virus (BmNPV) with an efficiency approaching 100% has been developed. In a specific example, the vector of the invention was used to generate expression of a FLAG-epitope tagged HIV tat interacting protein of 30 kDa (f-TIP30) in BmN cells and silkworm larvae.

System for rapid generation of recombinant baculovirus-based expression vectors for silkworm larvae

Histone acetyltransferase inhibitors, especially those that are differentiate between p300 and PCAF histone acetyltransferase; also therapeutic processes comprising their administration to humans.

Inhibitors of histone acetyltransferases (HATs) and uses thereof

Isolated nucleic acid molecules encoding Thyroid Receptor-Associated Proteins (TRAPS) are provided. TRAPS are members of protein complexes that bind to nuclear hormone receptors in a ligand-dependent manner so that the receptor, upon activation by a corresponding hormone, regulates the transcription of a particular gene. Also provided are methods of replicating and expressing such isolated nucleic acid molecules, pharmaceutical compositions comprising TRAPS, and methods of modulating gene expression via administration of therapeutically effective amounts of such pharmaceutical compositions.

Nucleic acid molecules encoding nuclear hormone receptor coactivators and uses thereof

Methods of isolating and characterizing Tat-interacting proteins (TIPs) are disclosed. These Tat-interacting proteins comprise a material selected from the group consisting of a protein, active fragments thereof, agonists thereof, mimics thereof, and combinations thereof, said protein having the following characteristics:

Cofactors for HIV-1 protein Tat and methods of use therefor

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New York, NY, United States of America

Robert G Roeder