Warner-lambert Company

Robert G Reisch, Jr

Mahdi B Fawzi

Gerard C Hokanson

Michael Ray Harris

Kuchi S Murthy

Frank Waldman

Isaac Ghebre-Sellassie

Russell U Nesbitt

Riten Parikh

A novel solid pharmaceutical dispersion that improves the bioavailability of poorly water soluble drugs is produced by combining the drug with a polymer carrier such as polyvinylpyrrolidone. The drug is combined with the carrier without the need for using organic solvents or melting temperatures (fusion) through the use of a transition compound such as polyethylene glycol which partially solubilizes the drug and/or plasticizes the polymer.

Solid pharmaceutical dispersions

The oxidation--and color-stability of certain ace inhibitors is optimized when they are formulated with a stabilizer and at least one lubricant and/or excipient.

Drug compositions stabilized against oxidation

The cyclization and hydrolysis of certain ACE inhibitors is minimized when they are formulated with a stabilizer and at least one lubricant and/or excipient.

Stabilized drug compositions

Growing community of inventors

Haledon, NJ, United States of America

Robert G Reisch, Jr