Smithkline Corporation

Robert G Pendleton

William Edward Bondinell

Carl Kaiser

Robert M DeMarinis

Jacob P Hieble

Paulette E Setler

Method of producing alpha.sub.2 antagonism by administering thiadiazolo- and oxadiazolotetrahydroisoquinoline compounds.

Method of producing alpha.sub.2 antagonism

1,2,3,4-Tetrahydroisoquinoline compounds having 7- and/or 8-sulfur substituents are inhibitors of phenylethanolamine N-methyltransferase.

7- and/or 8-Sulfur substituted 1,2,3,4-tetrahydroisoquinoline compounds

Pharmaceutical compositions and methods of inhibiting phenylethanolamine N-methyltransferase using novel 2,3-dihydro-1H-isoindole compounds having 4- and 5-substituents.

4- and 5-Substituted 2,3-dihydro-1H-isoindoles, pharmaceutical

Pharmaceutical compositions and methods of inhibiting phenylethanolamine N-methyltransferase using substituted carbamimidothioic acid phenylalkyl esters.

Pharmaceutical compositions and method of inhibiting phenylethanolamine

Pharmaceutical compositions and methods of inhibiting phenylethanolamine N-methyltransferase using 2-indanamine compounds having 4 and/or 5 substituents.

2-Indanamine compounds having 4 and 5-halo substituents are inhibitors of phenylethanolamine N-methyltransferase.

4 AND 5-Halo substituted 2-indanamine compounds

Pharmaceutical compositions and methods of inhibiting phenylethanolamine N-methyltransferase using 7 and/or 8 substituted 1,2,3,4-tetrahydroisoquinoline compounds.

Pharmaceutical compositions and methods of inhibiting phenylethanolamine

Pharmaceutical compositions and method of producing anti-Parkinsonism activity by administering internally a nontoxic effective quantity of a benzazepine derivative to an animal.

Pharmaceutical compositions and method of producing anti-Parkinsonism

Pharmaceutical compositions and a method of stimulating peripheral dopamine receptors by administering internally a nontoxic effective quantity of a benzazepine derivative to an animal. Renal vasodilator and diuretic methods are also disclosed.

Pharmaceutical compositions and methods involving benzazepine derivatives

1,2,3,4-Tetrahydroisoquinoline compounds having 7 and 8 halo substituents are inhibitors of phenylethanolamine N-methyltransferase.

Growing community of inventors

Philadelphia, PA, United States of America

Robert G Pendleton