Cornerstone Pharmaceuticals, Inc.

Rafael Pharmaceuticals, Inc.

Enzon, Inc.

Lifeblood Medical Inc.

Robert G L Shorr

Robert J Rodriguez

Rajinder Bhasin

David R Filpula

Marc D Whitlow

Lihsyng Standford Lee

Joseph Fischer

Jan Baker

Lihsyng Stanford Lee

Sanjeev Luther

The invention provides methods, compositions, and medical kits for treating pancreatic cancer using (i) 6,8-bis(benzylsulfanyl)octanoic acid or a pharmaceutically acceptable salt thereof in combination with (ii) gemcitabine or a pharmaceutically acceptable salt thereof, and (iii) nab-paclitaxel.

Therapeutic methods and compositions for treating pancreatic cancer using 6,8-bis-benzylthio-octanoic acid

Pharmaceutical formulations containing lipoic acid derivatives and ion pairs thereof are described. The pharmaceutical formulations are useful in the treatment of medical disorders, such as cancer.

Methods of treating leukemia using compositions containing bis(benzylthio)octanoic acid and ion pairs thereof

Methods for treating cancer using 6,8-bis (benzylthio) octanonic acid

Pharmaceutical formulations containing lipoic acid derivatives

The invention provides a method of treating myeloma and lymphoma using a pharmaceutical composition containing a pharmaceutically acceptable diluent along with an ion pair formed by triethanolamine and a compound of Formula I: 

Methods of treating myeloma and lymphoma using compositions containing an ion pair of a lipoic acid derivative

Methods of treating pancreatic and ovarian cancers using compositions containing an ion pair of a lipoic acid derivative

The invention provides a method of treating colon, lung, and liver cancers using a pharmaceutical composition containing a pharmaceutically acceptable diluent along with an ion pair formed by triethanolamine and a compound of Formula I: 

Methods of treating colon, lung, and liver cancers using compositions containing an ion pair of a lipoic acid derivative

The invention provides a method of treating leukemia using a pharmaceutical composition containing bis-benzyl lipoate, triethanolamine, and a pharmaceutically acceptable diluent, where the bis-benzyl lipoate and triethanolamine form an ion pair.

The invention provides ion pairs of a lipoic acid derivative and an ion pairing agent, pharmaceutical formulations containing such ion pairs, and methods of using the ion pairs and pharmaceutical formulations in the treatment of medical disorders, such as cancer. An exemplary ion pair is the ion pair formed by bis-benzyl lipoate and triethanolamine. The pharmaceutical formulations may comprise a dextrose solution as a diluent.

Nanoparticles made from a select group of lipids and optionally containing a therapeutically active agent are employed in pharmaceutical compositions for delivery to targeted tissues and/or cells for the treatment or diagnosis of such diseases as cancer.

Pharmaceutical and diagnostic compositions containing nanoparticles useful for treating targeted tissues and cells

The present invention relates to the chemical modification of single chain polypeptides by means of covalent attachment of strands of poly(ethylene glycol) PEG and similar poly(alkylene oxides) to single chain polypeptide binding molecules that have the three dimensional folding and, thus, the binding ability and specificity, of the variable region of an antibody. Such preparations of modified single chain polypeptide binding molecules have reduced immugenicity and antigenicity as well as having a longer halflife in the bloodstream as compared to the parent polypeptide. These beneficial properties of the modified single chain polypeptide binding molecules make them very useful in a variety of therapeutic applications. The invention also relates to multivalent antigen-binding molecules capable of PEGylation. Compositions of, genetic constructions for, methods of use, and methods for producing PEGylated antigen-binding proteins are disclosed.

Polyalkylene oxide-modified single chain polypeptides

The present invention is directed to methods of preserving mammalian heart, ex vivo. Nanoparticle compositions for carrying out the invention are also disclosed.

Composition for maintaining organ and cell viability

The present invention is directed to nanoparticle compositions for maintaining organ, tissue and cellular viability when such are separated from normal physiological supports. Compositions containing the nanoparticle compositions and methods of preserving organs such as kidneys, both in vivo and ex vivo, are also disclosed.

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Edison, NJ, United States of America

Robert G L Shorr