Genvivo, Inc.

Kosan Biosciences Incorporated

Epeius Biotechnologies Corporation

Other

Robert G Johnson, Jr

Rebecca A Reed

Joseph McNulty

John P Levy

Cecilia Roh

Jacqueline Fischer-lougheed

Yiqing Zhou

Bradford H Steele

Alison Hannah

Thomas Müller

Michael J Sherrill

Gillian F Cropp

Brile Chung

J Michael Sherrill

Described herein are compositions for delivering a therapeutic or vaccine. Also described herein are methods for using the compositions described herein for delivering a therapeutic or a vaccine.

Compositions and methods for therapeutic or vaccine delivery

Described herein are compositions comprising a recombinant retroviral vector for delivering a therapeutic comprising a nucleic acid construct comprising a polynucleotide sequence encoding an interleukin or a subunit thereof. Also described herein are methods of using the composition comprising a recombinant retroviral vector described herein for delivering a therapeutic comprising a nucleic acid construct comprising a polynucleotide sequence encoding an interleukin or a subunit thereof to a subject.

Compositions and methods for therapeutic delivery

Nucleic acid sequences encoding improved Herpes Simplex Virus Thymidine Kinases are provided, including their use in diagnostic and therapeutic applications. The thymidine kinases may be mutated using conservative mutations, non-conservative mutations, or both. Also provided are gene therapeutic systems, including viral and retroviral particles.

Thymidine kinase gene

Thymidine kinase diagnostic assay for gene therapy applications

Method for identifying and treating a patient having tumor lesions comprising administering a gene therapy retroviral vector particle comprising a mutated HSV-thymidine kinase (HSV-TK) polynucleotide

The present invention provides a method for treating cancer. The method involves the administration of an HSP90 inhibitor and an antimitotic, where the combined administration provides a synergistic effect. In one aspect of the invention, a method of treating cancer is provided where a subject is treated with a dose of an HSP90 inhibitor in one step and a dose of an antimitotic in another step. In another aspect of the invention, a method of treating cancer is provided where a subject is first treated with a dose of an HSP90 inhibitor and subsequently treated with a dose of an antimitotic. In another aspect of the invention, a method of treating cancer is provided where a subject is first treated with a dose of an antimitotic and subsequently treated with a dose of an HSP90 inhibitor.

Method for treating diseases using HSP90-inhibiting agents in combination with antimitotics

A method for treating multiple myeloma in a subject by administering 17-allylamino-17-demethoxy-geldanamycin or 17-amino geldanamycin, or a prodrug of either 17-AAG or 17-AG, to the subject.

Method of treating multiple myeloma using 17-AAG or 17-AG or a prodrug of either

Formulations comprising one or more epothilones together with a pharmaceutically acceptable carrier, in particular such pharmaceutical compositions suitable for oral administration of an epothilone.

Therapeutic formulations

An apparatus including a playing board defined by a generally circular configuration, including a planar top surface with four equally spaced recessed triangulated player sections, wherein each player section includes a predetermined number of numbered recesses therewithin to correspond with four different colored sets of correspondingly numbered spheres. The spheres are positionable within a rotating tumbler and are permitted to be removed from the tumbler in a one-at-a-time sequence for selective association with one of said recesses. A further series of white spheres and a further series of black spheres are provided to direct respectively a free turn for the player and 'wild' spheres for the black spheres for use with any number or coloration. Each player must utilize a corresponding coloration for a corresponding player position. Additionally, a plurality of dice are utilized to direct play in sequence about the board game. The tumbler apparatus utilized permits the balls to be directed from the tumbler through an opening that upon being positioned in a downward orientation permits a single sphere to be removed. A player to associate a sequence of spheres in a sequential array in association with a BINGO arrangement is declared a winner.

Growing community of inventors

Lafayette, CA, United States of America

Robert G Johnson, Jr