Warner-lambert Company

Robert Frederick Meyer

William Alexander Denny

Alexander James Bridges

Gordon William Rewcastle

David W Fry

Andrew Mark Thompson

Alan Kraker

Milton L Hoefle

Howard D Showalter

Howard Daniel Hollis Showalter

Tricyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family

Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family

Described are compositions and a method of inhibiting epidermal growth factor receptor tyrosine kinase by treating, with an effective inhibiting amount, a mammal, in need thereof, a compound of Formula II:

Novel 4-substituted amino pyrido [3,2-d]pyrimidine inhibitors of epidermal growth factor receptor family of tyrosine kinases are described, as well as pharmaceutical compositions of the same, which are useful in treating proliferative diseases such as cancer, synovial pannus invasion in arthritis, psoriasis, vascular restenosis and angiogenesis and additionally useful in the treatment of pancreatitis and kidney disease as well as a contraceptive agent.

Substituted pyrido[3,2-d]pyrimidines capable of inhibiting tyrosine

Novel 4-substituted amino benzothieno�3,2-d!pyrimidine and 4-substituted amino�2,3-d!pyrimidine inhibitors of epidermal growth factor receptor family of tyrosine kinases are described, as well as pharmaceutical compositions of the same, which are useful in treating proliferative diseases such as cancer, synovial pannus invasion in arthritis, psoriasis, vascular restenosis and angiogenesis and additionally useful in the treatment of pancreatitis and kidney disease as well as a contraceptive agent.

Tricyclic compounds capable of inhibiting tyrosine kinases of the

Novel 4-substituted amino pyrido pyrimidine and 4-substituted amino pyrido pyrimidine inhibitors of epidermal growth factor receptor family of tyrosine kinase are described, as well as pharmaceutical compositions of the same, which are useful in treating proliferative diseases such as cancer, synovial pannus invasion in arthritis, psoriasis, vascular restenosis and angiogenesis and additionally useful in the treatment of pancreatitis and kidney disease as well as a contraceptive agent.

Bicyclic compounds capable of inhibiting tyrosine kinases of the

Novel N-(substituted-phenyl)-5-(2,5-dimethylphenoxy)-2,2-dimethylpentanamides which are useful in preventing the intestinal absorption of cholesterol, as well as novel pharmaceutical compositions and methods of use, as well as processes for their manufacture are herein described.

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Ann Arbor, MI, United States of America

Robert Frederick Meyer