A. H. Robins Company, Incorporated

Boehringer Ingelheim Chemicals, Inc.

Boehringer Ingelheim International Gmbh

Robert Frederick Boswell, Jr

Young Sek Lo

Robert Louis Duncan, Jr

Frank B Gupton

Christopher P Johnson, Iii

Jack Delbert Brown

Ahmad Khodabocus

Kai Oliver Donsbach

Cary Mark Davis

Saeed Ahmad

Vithalanand R Kulkarni

An improved process for making 5,11-dihydro-11-ethyl-5-methyl-8-{2-{(1-oxido-4-quinolinyl)oxy}ethyl}-6H-di pyrido[3,2-b:2',3&#x2032;-e][1,4]diazepin-6-one.

Process for making 5,11-Dihydro-11-ethyl-5-methyl-8{2-{(1-oxido-4-quinolinyl)oxy}ethyl}-6H-di pyrido[3,2-b:2',3&#x2032;-e][1,4]diazepin-6-one

Method for making nevirapine

Preparation of amphetamines from phenylpropanolamines

1-Substituted-3-aminoethoxypyrrolidines possessing hypotensive properties are disclosed. The compounds are prepared from 3-aminoethoxypyrrolidines.

1-Substituted-3-aminoethoxypyrrolidines

Novel 1-substituted-4-benzylpiperidines having .alpha.-substituents on the 4-benzyl moiety useful as anti-inflammatory agents, sedatives, and tranquilizers are represented by the formula ##STR1## wherein R represents acetyl, aryloxyloweralkyl, aroylloweralkylcarbamoyl, N-lower-alkylcarbamoyl, N,N-dilower-alkylcarbamoyl, N-arylcarbamoyl, N-(.omega.-nitrogen containing heterocycle)lower-alkylcarbamoyl, N(-.omega.-aminolower-alkyl)carbamoyl, 2-hydroxy-3-(o-methoxyphenoxy)propyloxycarbonyl, 2-carbamoylethyl, or 4-(p-fluorobenzoyl)piperidinoethyl; R.sup.1 represents hydrogen or hydroxy; R.sup.2 represents phenyl, p-fluorophenyl, m-trifluoromethylphenyl or cyclohexyl; Y represents hydrogen or fluorine with the proviso that when Y is hydrogen and R.sup.2 is phenyl, R is other than aroylloweralkyl. The pharmaceutically acceptable acid addition salts of the basic compounds of Formula I are included as part of the invention.

1-Substituted-4-benzylpiperidines

Novel 1-substituted-4-benzylpiperidines having .alpha.-substituents on the 4-benzyl moiety useful as antiinflammatory agents, sedatives, and tranquilizers are represented by the formula ##SPC1## Wherein R represents acetyl, aryloxyloweralkyl, aroylloweralkylcarbamoyl, N-lower-alkylcarbamoyl, N,N-dilower-alkylcarbamoyl, N-arylcarbamoyl, N-(.omega.-nitrogen containing heterocycle)lower-alkylcarbamoyl, N-(.omega.-aminolower-alkyl)carbamoyl, 2-hydroxy-3-(o-methoxyphenoxy)propyloxycarbamoyl, 2-carbamoylethyl, or 4-(p-fluorobenzoyl)piperidinoethyl; R.sup.1 represents hydrogen or hydroxy; R.sup.2 represents phenyl, p-fluorophenyl, m-trifluoromethylphenyl or cyclohexyl; Y represents hydrogen or fluorine with the proviso that when Y is hydrogen and R.sup.2 is phenyl, R is other than aroylloweralkyl. The pharmaceutically acceptable acid addition salts of the basic compounds of Formula I are included as part of the invention.

Growing community of inventors

Richmond, VA, United States of America

Robert Frederick Boswell, Jr