Five Prime Therapeutics, Inc.

Robert Forgan Halenbeck

Lewis T Williams

Stephen Kohl Doberstein

Kevin Hestir

Ernestine A Lee

Shannon Marshall

Elizabeth Bosch

Haishan Lin

Cindy Leo

Ge Wu

Aileen Zhou

Justin G P Wong

Min Mei Huang

Thomas Linnemann

Dirk Behrens

Justin G Wong

Steven Doberstein

Thomas Five Prime Therapeutics Inc Linnemann

Disclosed is a newly identified secreted molecule, identified herein as 'monocyte, granulocyte, and dendritic cell colony stimulating factor' (MGD-CSF), the polypeptide sequence, and polynucleotides encoding the polypeptide sequence. Also provided is a procedure for producing the polypeptide by recombinant techniques employing, for example, vectors and host cells. Additionally, procedures are described to modify the disclosed novel molecules of the invention to prepare fusion molecules. Also disclosed are methods for using the polypeptides and active fragments thereof for treatment of a variety of diseases, including, for example, cancer, autoimmune and inflammatory diseases, infectious diseases, and recurrent pregnancy loss.

Compositions and methods of use for MGD-CSF in disease treatment

Growing community of inventors

San Francisco, CA, United States of America

Robert Forgan Halenbeck