University of Pittsburgh

Other

University System of Maryland

Vegenics Pty Limited

Vegenics Limited

Robert Ferrell

David Finegold

Kari Alitalo

Marika Karkkainen

Michael B Gorin

Yvette P Conley

Johanna Jakobsdottir

Daniel E Weeks

Tammy S Mah-Fraser

James Hagberg

Catherine Baty

Bernie J Devlin

Bora E Baysal

Joan E Willett-Brozick

Michael Brown

Michael D Brown

Methods are provided for identifying risk of developing lymphedema, including primary and secondary edema. The methods comprise identifying the presence in a biological sample of a polymorphism in one or more of GJA4, GJA5 and GJC2, resulting in a functional mutation of one or more of connixin 37 (Cx37), Cx40 or Cx47.

Connexin mutation detection for lymphatic variation and disease

The present invention provides materials and methods for screening for and treating hereditary lymphedema in human subjects.

Method of treatment for lymphedema comprising administering a polynucleotide encoding VEGF-D

Allelic variations in the genes PLEKHA1 and LOC387715 are identified herein as risk factor for Age Related Maculopathy (ARM). A method is therefore provided for identifying a risk of development of ARM in an individual that comprises identification of allelic variations in PLEKHA1 and/or LOC387715. Related apparatus, such as an array, are identified as being useful in implementing those methods.

Susceptibility genes for age-related maculopathy (ARM) on chromosome 10q26

Method of treating lymphedema comprising administering VEGF-D

Screening for lymphatic disorders involving the FLT4 receptor tyrosine kinase (VEGFR-3)

A method of increasing sodium excretion levels in a hypertensive subject by identifying a subject having an II genotype for an angiotensin converting enzyme gene, and engaging the subject in limited exercise training for a period of time sufficient to increase the subject's sodium excretion levels.

ACE genotype which correlates with improved success in sodium excretion in hypertensives with exercise

The present invention is directed to oxygen sensing. The present invention provides methods for correcting (or providing for) oxygen sensing in cells. Preferably, the methods involve supplying the SDHD gene or cybS protein, or any of the other components of the mitochondrial complex II cytochrome b oxygen sensing complex in an amount which restores oxygen sensing to affected cells, and thus facilitates normoxic conditions. More specifically, the present invention relates to mutations in the SDHD gene in human cancers and their use in the diagnosis and prognosis of mammalian cancer.

Oxygen sensing and hypoxic selection for tumors

Methods of reducing blood pressure levels in hypertensive subjects through the identification of subjects with an allele and/or genotype at a gene locus that positively correlates with improved success in reducing blood pressure levels, as compared to other alleles and/or genotypes at the same gene locus, and through the engagement of these subjects in exercise training for a period of time sufficient for the reduction of the subjects' blood pressure levels.

Genetic markers which identify individuals who decrease their blood pressure through exercise

A display unit is disclosed in which a frame assembly magnetically supports a plurality of removable display strips in predetermined patterns and in which alpha-numeric character elements are magnetically supported on the display strips and frame assembly in information displaying sets referenced in part by markings located on the surface of the display strips.

Display board

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Pittsburgh, PA, United States of America

Robert Ferrell