Southern Research Institute

Other

Robert F Struck

Herbert M Blatter

Anita Tiwari

John A Secrist, Iii

James R Piper

Jerry M Collins

Eric K Rowinsky

John M Strong

Seamus O'Reilly

Carroll Temple

Neil Hartman

Donald R Kahn

Thiocarbonate and thiocarbamate derivatives of 4-demethylpenclomedine are provided along with pharmaceutical compositions containing them and use for treating cancer. A method for preparing the derivatives is also provided.

Derivatives of 4-demethylpenclomedine, use thereof and preparation thereof

Method for prevention or treatment of acute allograft rejection and a pharmaceutical composition therefor

New pyridine compounds are provided along with their method of preparation. The compounds are useful as intermediates in preparing new anticancer agents. A few of the pyridine compounds are also useful for treating cancer.

Pyridine compounds, use and preparation thereof

Pyridine compounds use and preparation thereof

Acyl derivatives of 4-demethylpenclomedine are provided along with pharmaceutical compositions containing them and use for treating cancer. A method for preparing the derivatives is also provided.

Acyl derivatives of 4-demethylpenclomedine, use thereof and preparation thereof

Substantially pure 3,5-dichloro-2-nethoxy-4-hydroxy-6-(trichloromethyl)pyridine or 4-demethylpenclomedine (formula I), acid addition salts thereof, pharmaceutical compositions containing the aforesaid compound, and a method of using the compound in the treatment of cancer in a mammal are disclosed.

Compound, composition and method for treating cancer

Isophosphoramide mustard analogs useful for treating cancer are provided.

Isophosphoramide mustard analogs and use thereof

Growing community of inventors

Birmingham, AL, United States of America

Robert F Struck