Bristol-Myers Squibb Compnay

Robert F Mayol

Joseph P Yevich

Jianqing Li

Frank D Yocca

Ronald J Mattson

George Michael Luke

Michael E Brady

The S-stereoisomer of 6-hydroxy-buspirone is an effective treatment for anxiety, depression, and other psychogenic disorders. The S-isomer may provide reduced potential for adverse effects and a longer duration of action compared to the racemic mixture and with buspirone.

S-6-hydroxy-buspirone

The R-stereoisomer of 6-hydroxy-buspirone is an effective treatment for anxiety, depression, and other psychogenic disorders. The R-isomer exhibits greater receptor specificity than the S-isomer and should have reduced potential for the adverse effects associated with the racemic mixture and with buspirone.

R-6-hydroxy-buspirone

6-Hydroxy-8-[4-[4-(2-pyrimidinyl)-piperazinyl]-butyl]-8-azaspiro[4.5]-7,9-d ione and its pharmaceutically acceptable salts and hydrates are useful in the alleviation of anxiety.

Anxiety method

2-(3-[4-(3-Halophenyl)-1-piperazinyl]propyl derivatives of certain 4-alkyl- or 4-phenoxyalkyl-2,4-dihydro-3H-1,2,4-triazol-3-ones and triazol-3,5-diones are psychotropic agents having promise as antidepressants by virtue of their receptor site binding affinity profiles and animal pharmacology.

Antidepressant 3-halophenylpiperazinylpropyl derivatives of substituted

A series of pyprimidinyl compounds of formulae I, II and III; ##STR1## wherein R.sup.1 and R.sup.2 are independently selected from hydrogen and hydroxy;

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Burns, TN, United States of America

Robert F Mayol