Abbott Laboratories Corporation

Novartis Ag

Other

Robert F Keyes

Hing L Sham

Rolf Wagner

Martin Sendzik

James Clifford Sutton

Keith Bruce Pfister

Paul Andrew Barsanti

Xenia Beebe Searle

Xiaodong Lin

Curt S Cooper

Cheng Hu

Lifeng Wan

Douglas M Kalvin

David D Anderson

Yue Pan

Jeff Xianming Jin

Mira Hinman

Bruce A Beutel

Yu-Gui Gu

Robert Kucejko

Yat Sun Or

Gang Liu

Philip R Kym

Zhili Xin

Zhenkun Ma

Richard F Clark

Todd M Hansen

Rajesh R Iyengar

Andrew S Judd

Albert V Thomas

Yu Gui Gu

Gang Zhao

Ramiya H Premchandran

Hemant H Patel

Hongyu Zhao

Anne H Kemp

Tianyuan Zhang

Mei Liu

Ernst U Frevert

Barbara L Cool

Yugui Gu

The present invention provides a compound of formula (I): 

Heteroaryl compounds and their uses

The present invention provides a compound of formula (I): and pharmaceutically acceptable salts, enantiomers, stereoisomers, rotamers, tautomers, diastereomers, or racemates thereof. Also provided is a method of treating a disease or condition mediated by CDK9.

The present invention relates to compounds of formula (I) which inhibit acetyl-CoA carboxylase (ACC) and are useful for the prevention or treatment of metabolic syndrome, type II diabetes, obesity, atherosclerosis and cardiovascular diseases in humans.

Acetyl-CoA carboxylase (ACC) inhibitors and their use in diabetes, obesity and metabolic syndrome

Bacterial protein synthesis-inhibiting compounds having formula (I)  and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates in the processes, compositions containing the compounds, and methods of using the compounds are disclosed.

Antibacterial compounds

Bacterial protein synthesis-inhibiting compounds having formula (I) and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates in the processes, compositions containing the compounds, and methods of using the compounds are disclosed.

The present invention relates to compounds that activate AMP-activated protein kinase (AMPK), including the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders such as diabetes, metabolic syndrome, and obesity.

Thienopyridones as AMPK activators for the treatment of diabetes and obesity

9a-azalides with antibacterial activity

The claimed invention relates to a novel process of preparing N-demethyl-N-alkyl-4'-deoxy erythromycin A and B. The process comprises protecting the 2'-hydroxy or the 2'- and 11-hydroxy of a N-demethyl-4'-deoxy erythromycin derivative having the formula: ##STR1## where R.sub.b is H or OH, with a silyl protecting group and alkylating the N-position of the desosamine sugar.

Process for preparing N-demethyl-N-alkyl erythromycin derivatives

Growing community of inventors

Kenosha, WI, United States of America

Robert F Keyes