Merck + Co., Inc.

Robert F Czaja

Edward J Grabowski

Seemon H Pines

Roger J Tull

Richard F Shuman

Newton L Abramson

John Budavari

Arthur J Zambito

William F Shukis

Crystalline salts of (R,S)-pivaloyloxyethyl esters of (S)-3-(3,4-dihydroxyphenyl)-2-methylalanine, processes for their preparation and pharmaceutical composition are disclosed.

Crystalline salts of L or (S)-3-(3,4-dihydroxyphenyl)-2-methylalanine

This invention relates to an improved process for preparing 5-fluoro-2-methyl-1-(p-methylsulfinylbenzylidene)-3-indenyl acetic acid.

Process for preparing indenyl acetic acids

New 7-(Amidinothio)acetamido-7-methoxy-3-carbamoyloxymethyl-3-cephem-4-carboxy lic acid compounds are prepared which are useful as antibacterial agents, especially Pseudomonas.

7-(Amidinothio)acetamido-7-methoxy cephalosporins

Process for preparing 5-fluoro-2-methyl-1-(p-methylsulfinylbenzylidene)-indene-3-acetic acid by reacting fluorobenzene with an acid halide, to form an indanone, reaction of the indanone with a methylthio (or methylsulfinyl) benzyl compound to form 5-fluoro-2-methyl-1-(p-methylthiobenzyl) or (p-methylsulfinylbenzyl)-indene and reacting said indene with a glyoxylic acid. This invention relates to new processes for preparing 5-fluoro-2-methyl-1-(p-methylsulfinylbenzylidene)-indene-3-acetic acid, to intermediates thereof and processes for said intermediates.

Process for preparing indene acetic acids

Haloalkyl derivatives of aromatic compounds are prepared via reaction with dialkoxy or aralkoxy alkanes in the presence of a Lewis acid.

Chemical compounds and processes

Process for preparing 5-fluoro-2-methyl-1-(p-methylsulfinylbenzylidene)-indene-3-acetic acid by reacting fluorobenzene with an acid halide, to form an indanone, reaction of the indanone with a methylthio (or methylsulfinyl)benzyl compound to form 5-fluoro-2-methyl-1-(p-methylthiobenzyl) or (p-methylsulfinylbenzyl)-indene and reacting said indene with a glyoxylic acid. The invention also relates to intermediates thereof and processes for said intermediates.

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Scotch Plains, NJ, United States of America

Robert F Czaja