Mcneil-ppc, Inc.

Noramco Gmbh

Robert E Wingard, Jr

Nicholas M Vernon

Robert E Walkup

Juan L Navia

David S Neiditch

George H Sankey

Sucrose is mono-acylated in the 6-position by reacting sucrose with a carboxylic acid anhydride such as acetic or benzoic anhydride in a reaction mixture containing a polar aprotic solvent and a catalytic quantity of a 1,3-diacyloxy-1,1,3,3-tetra(hydrocarbyl)distannoxane, for a period of time and at a temperature sufficient to produce a sucrose-6-ester.

Catalyzed sucrose-6-ester process

A process for producing substantially pure sucralose pentaester from a mixture of 6-O-acyl-4,1' ,6' -trichloro-4,1',6'-trideoxygalactosucrose in a reaction medium comprising a tertiary amide, wherein said process comprises the steps of:

Sucralose pentaester production

There is disclosed a process which comprises the steps of:

Selective 6-acylation of sucrose mediated by cyclic adducts of

Process which comprises reacting sucrose with a di-(hydrocarbyl)tin oxide in an inert organic reaction vehicle with removal of water for a period of time and at a temperature sufficient to produce a 1,3-di-(6-O-sucrose)-1,1,3,3-tetra(hydrocarbyl)distannoxane.

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Athens, GA, United States of America

Robert E Wingard, Jr