Musc Foundation for Research Development

Robert E Stroud

Francis G Spinale

Michael R Zile

Anne Deschamps

Michael Looper

Disclosed herein are methods of detecting and predicting diastolic heart failure and predicting congestive heart failure comprise protease and protease inhibitor profiling.

Detecting diastolic heart failure by protease and protease inhibitor plasma profiling

Provided are systems and methods for detecting and/or measuring in vivo interstitial biological activity, processes, and or compounds in human or animal subjects.

Systems and methods for in vivo measurement of interstitial biological activity, processes and/or compositions

Disclosed are methods and materials for assessing cardiac failure, cardiac hypertrophy, and left ventricular remodeling using microRNA levels. The level of microRNAs can be measured in a body fluid, such as plasma and serum.

Assessing left ventricular remodeling via temporal detection and measurement of microRNA in body fluids

Disclosed herein are methods of detecting or predicting diastolic heart failure in a subject, comprising identifying a profile of matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs) from a body fluid of the subject that is associated herein with the existence of likely development of left ventricular dilation (LVD).

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Mt. Pleasant, SC, United States of America

Robert E Stroud