Merck + Co., Inc.

Robert E Schwartz

Jerrold M Liesch

Robert A Giacobbe

Otto D Hensens

Gerald F Bills

Deborah L Zink

Janet C Onishi

James M Balkovec

Milton L Hammond

Fernando Pelaez

Dennis M Schmatz

Sagrario M Del Val

Maria T Diez

David F Sesin

Francisca Vicente

Carol F Wichmann

Richard L Monaghan

Raymond F White

John R Thompson

Suzanne M Mandala

Prakash S Masurekar

James E Curotto

Rosemary A Thornton

August J Kempf

Wendy S Horn

Angeles Cabello

Maria S Meinz

Fernando Pelaez Perez

Angeles Cabello Arroyo

Thomas C Hallada

Evon A Bolessa

Isabel Martin Fernandez

Teresa Diez Matas

Charles F Hirsch

Isabella Martin

David J Mathre

Sheldon B Zimmerman

Kenneth E Wilson

Anne W Dombrowski

Henry Joshua

Douglas J Pettibone

Gregory L Helms

Sandra A Morris

Jan S Tkacz

Richard K Jansson

Michael J Salvatore, Jr

James A Milligan

Ruth S Sykes

Francisca Vicente Perez

Mervyn J Turner

Janet M Sigmund

Mark Rattray

Julian Gorrochategui

Barnali Pramanik

Francisca Vincente Perez

Robert A Fromtling

Disclosed is a method for controlling phytopathogenic fungi using pure strains of ATCC 74386 and fungus ATCC 74387. Further, methods of producing a sordarin compound are disclosed. The method includes cultivating each strain separately in a nutrient medium containing assimilable sources of carbon and nitrogen and recovering the compound. A sordarin compound of formula I is also disclosed. Also an antifungal composition containing a sordarin compound is also disclosed.

Rosellinia subiculata ATCC 74386 and fungus ATCC 74387 for producing sordarin compounds for fungi control

There is disclosed a novel compound having the formula ##STR1## which exhibits antifungal activity.

Antifungal agent obtained from hormonema

There is disclosed a compound having the formula ##STR1## which is produced by the fungus, Arthrinium arundinis ATCC 74359, and exhibits antifungal activity.

Antifungal agent produced by arthrinium arundinis  ATCC 74359

A compound having the formula ##STR1## which is an anti-fungal agent is described. The producing organism Colletotricum accutatum is also described, along with a method of production.

Anti-fungal agents

There are disclosed lipopeptide derviatives of the general formula: ##STR1## where the substituents are defined herein which have antifungal and antiprotozoal activity. There are also disclosed pharmaceutical compositions containing these compounds.

Lipopeptide derivatives

The present invention is directed to water-soluble derivatives of antibiotic lipopeptides. The derivatives have good solubility properties in aqueous medium, rendering them more useful as therapeutic agents.

A new antibiotic cyclic lipopeptide having the formula ##STR1## wherein R is H or OH and a method of producing is described. The agent has very high activity against human pathogens and is of very low mammalian toxicity.

Antibiotic agent

A compound of the formula 1: ##STR1## is produced via fermentation of a fungal isolate ATCC no. 74235. The organism is included herein, as well as a process for production of the compound, a pharmaceutical composition and a method of treatment.

Antifungal compound and compositions containing the compound

A process for obtaining a compound of the formula ##STR1## in crystalline form by solubilizing the compound in warm aqueous n-propanol and then allowing the solution to stand at ambient temperature until crystal formation is substantially complete is described. The crystalline compound obtained thereby is also described.

Process for crystalline cyclic lipopeptides

A cyclohexapeptide base which is the nucleus of closely related antibiotics obtained by culturing Zalerion arboricola and its salts are described. They are useful intermediates for the preparation of new semisynthetic compounds having antimicrobial activity.

Cyclohexapeptide compound

A new antibiotic cyclic lipopeptide having the formula ##STR1## wherein R is H SEQ ID NO:1 or OH SEQ ID NO:2 and a method of producing is described. The agent has very high activity against human pathogens and is of very low mammalian toxicity.

An antibiotic agent produced by the cultivation of Zalerion arboricola which is a cyclic lipopeptide with very high activity against human pathogens and of very low mammalian toxicity is described. Its production and isolation are also described.

Antibiotic cyclopeptide fermentation product

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Westfield, NJ, United States of America

Robert E Schwartz