E.i. Dupont De Nemours and Company

Bristol-myers Squibb Pharma Company

New England Nuclear Corporation

Robert E Lewis

Fu-Min Su

Prahlad R Singh

Gerald P Tercho

Keith R Olewine

Timothy A Lane

Peter S Holton

Paul R Walsh

Methods and apparatus for separating ions of metallic elements are provided. Preferred methods utilize a hydrophobic chelating extractant, such as an organophosphorus compound, adsorbed onto carbon or graphite fibers in the form of felt. Also described is a new thallium-201 generator that comprises a column containing an acidic organophosphorus extractant adsorbed on carbon or graphite fibers, and a yttrium-90 generator system comprised of two extraction columns designed to selectively absorb yttrium-90 at different pH, to enable the separation of yttrium-90 from strontium-90. The two columns are connected in series for stepwise separation. The yttrium-90 product is freed from residual strontium-90 and metal contaminants and can be eluted from the second column with dilute acid, acetate buffer, water or saline for labeling biological targeted molecules. The new generator system provides rapid and efficient separation of yttrium-90 and is amenable to both scale-up and automation. Also described is a newTc generator that comprises a column containing an acidic organophosphorus extractant adsorbed on carbon or graphite fibers designed to selectively absorbMo at a selected pH, to enable the separation ofTc fromMo.

Method and apparatus for separating ions of metallic elements in aqueous solution

An intra-coronary radiation devices containing Ce-144 or Ru-106 deposited onto a wire and coated with a biocompatible material and methods of making and using the same.

Intra-coronary radiation devices containing Ce-144 or Ru-106

A method for generating Ga-68 from Ge-68 is provided that comprises contacting a substrate on which Ge-68 has been adsorbed with an alkaline solution having a pH of at least about 12 and thereby eluting Ga-68. Preferably the Ga-68 is eluted in the form of the gallate ion. A generator system comprises a generator column containing Ge-68 and Ga-68, a sealed eluant container having a predetermined quantity of eluant comprising an alkaline solution having a pH of at least about 12, and an evacuated eluate collection vial having a vacuum sufficient to draw the desired quantity of eluate into the eluate collection vial. The eluate collection vial can contain a neutralizing agent and also a diagnostically useful complexing agent.

Method and system for generating and collecting gallium-68 using

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Milford, NH, United States of America

Robert E Lewis