Venatorx Pharmaceuticals, Inc.

Robert E Lee Trout

Christopher J Burns

Denis Daigle

Daniel C Pevear

Bin Liu

Daniel McGarry

Randy W Jackson

Jodie Hamrick

Steven Armen Boyd

Allison L Zulli

Eugen F Mesaros

Stephen M Condon

Guo-Hua Chu

Zhenrong Xu

Lawrence Rosen

Cullen L Myers

Matthew Lucas

Robert Simpson

Daniel Mcgarry

Yijun Deng

Described herein are certain boron-containing compounds, compositions, preparations and their use as modulators of the transpeptidase function of bacterial penicillin-binding proteins and as antibacterial agents. In some embodiments, the compounds described herein inhibit penicillin-binding proteins. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.

Penicillin-binding protein inhibitors

Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.

Beta-lactamase inhibitors

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Collegeville, PA, United States of America

Robert E Lee Trout