Sterling Drug Inc.

Sterling Winthrop Inc.

Robert E Johnson

Donald C Schlegel

Alan M Ezrin

Carl A Busacca

Thomas E D'Ambra

Aryl-fused- and hetaryl-fused-2,4-diazepines of formula XXXVI, benzodiazocines of formula XXX, benzodiazepines of formula II ##STR1## .delta.-aminoamides of formula III and aryldimethanamines of formula XXXVII ##STR2## wherein A is an aryl or hetaryl ring;

Aryl-fused and hetaryl-fused-2,4-diazepine and 2,4-diazocine

Novel diarylamidines, and compositions and methods for treating cardiac arrhythmias in mammals utilizing the novel and related known diarylamidines of formula I, II, III and IV ##STR1##

Antiarrhythmic diarylamidines

Novel 2,5-benzodiazocines of formulas II and IV, pharmaceutical compositions containing them, processes for preparing them and methods of treating cardiac arrhythmias in mammals utilizing them. ##STR1##

2,5-benzodiazocine antiarrhythmic agents

Novel imidazo[2,1-b][3]benzazepines and pyrimido[2,1-b][3]benzazepines of formula I, pharmaceutical compositions containing them, methods for treating cardiac arrhythmia in mammals utilizing them, and processes for synthesizing them. ##STR1##

Imidazo[2,2-b][3]benzazepine and pyrimido[2,1-b][3]benzazepine

Novel imidazo[1,2-b][2]benzazepines and pyrimido[1,2-b][2]benzazepines of formula I, pharmaceutical compositions containing them, methods for treating cardiac arrhythmias in mammals utilizing them, and processes for synthesizing them. ##STR1##

Imidazo [1,2-b][2]benzazepine and pyrimido [1,2-b][2]benzazepine

N-(.omega.-cyanoalkyl)aminophenols of formula ##STR1## useful as lipoxygenase inhibitors and anti-asthmatic agents, are prepared by acylation of an aminophenol with an .omega.-haloalkanoyl chloride followed by reduction of the resulting amide then displacement of the halide by cyanide.

N-(.omega.-cyanoalkyl)aminophenols and use as inhibitors of lipoxygenase

1-(Phenylamino)pyrrole, useful as a urinary antiseptic, hypotensive and hypoglycemic agent, is prepared by reaction of an N-benzoylphenylhydrazine or N-lower-alkanoylphenylhydrazine or a lower-alkanealdehyde N-benzoylphenylhydrazone or N-lower-alkanoylphenylhydrazone with a 2,5-di-lower-alkoxytetrahydrofuran followed by hydrolytic removal of the benzoyl or lower-alkanoyl group from the resulting N-benzoyl-1-(phenylamino)pyrrole or N-lower-alkanoyl-1-(phenylamino)pyrrole.

1-(Phenylamino)pyrrole

1-(Arylamino)pyrroles and 1-(arylimino)pyrroles, useful as antibacterial agents, are prepared by reaction of an arylhydrazine or arylhydrazone with a 2,5-di-lower-alkoxytetrahydrofuran or with an alkanedione; by reaction of a 1-arylaminopyrrole with an oxalyl dihalide followed by oxidative hydrolysis of the product; by condensation of a 1-aminopyrrole with a quinone; or by oxidation or reduction of a respective 1-(arylamino)pyrrole or 1-(arylimino)pyrrole.

Growing community of inventors

East Greenbush, NY, United States of America

Robert E Johnson