The University of British Columbia

Other

University of Saskatchewan

Dalhousie University

International Vaccines Institute

International Vaccine Institute

Robert E Hancock

Kevin L Piers

Melissa H Brown

Nedra Karunaratne

Andrew A Potter

Lorne A Babiuk

Volker Gerdts

Jennifer Kovacs-Nolan

Mi-Na Kweon

Niamh Kelly

Melissa Elliott

Jason Kindrachuk

Song Lee

George Mutwiri

Scott Halperin

Artem Cherkasov

Sylvia Van Den Hurk

Kai Hilpert

Christopher Fjell

Sylvia Van Drunen Littel-van Den Hurk

Methods and compositions for enhancing an immune response to a selected antigen are described. The methods are useful for the treatment and prevention of microbial infections, such as infections caused by bacteria, viruses, fungi and parasites. The methods and compositions include host defense peptides, polyphosphazenes and immunostimulatory sequences to enhance the immune response to a coadministered antigen.

Combination adjuvant formulation

A novel class of cationic peptides having antimicrobial activity is provided. Examples of such peptides include NH.sub.2 --KWKSFIKKLTTAVKKVLTTGLPALIS--COOH (SEQ ID NO:1) and NH.sub.2 --KWKSFIKKLTSAAKKVVTTAKPLISS--COOH (SEQ ID NO:2). Also provided are methods for inhibiting the growth of bacteria utilizing the peptides of the invention. The peptides are particularly useful for inhibiting endotoxemia in a subject.

Antimicrobial cationic peptides

A novel class of cationic peptides having antimicrobial activity is provided. Examples of such peptides include

A novel class of cationic peptides having antimicrobial activity is provided. Examples of such peptides include NH.sub.2 -KWKSFIKKLTTAVKKVLTTGLPALIS-COOH (SEQ ID NO:1) and NH.sub.2 -KWKSFIKKLTSAAKKVVTTAKPLISS-COOH (SEQ ID NO:2).

A method for the microbial production of a cationic peptide having anti-microbial activity is provided, wherein the cationic peptide is first produced as a fusion protein having an anionic portion for suppressing the antimicrobial activity of the cationic portion. A novel cationic peptide having anti-microbial activity and LPS-binding activity is also provided. Such peptides are useful for suppressing the growth of bacteria and for the treatment of endotoxemia-associated disorders.

Treatment of endotoxin-associated disorders with cationic peptides

Method for recombinant production of cationic peptides and a novel polycationic antibacterial peptide.

CEMA cationic peptide and polynucleotides encoding cEMA

A method for the microbial production of a cationic peptide having anti-microbial activity is provided, wherein the cationic peptide is first produced as a fusion protein having an anionic portion for suppressing the antimicrobial activity of the cationic portion. A novel cationic peptide having anti-microbial activity is also provided.

Cationic peptides and method for production

Growing community of inventors

Vancouver, Canada

Robert E Hancock