The General Hospital Corporation

Oregon Health & Science University

Oregon State University

Shiseido Company, Limited

Tufts University

University School of Medicine

Robert E Burgeson

William Joseph Brunken

Jiro Kishimoto

Manuel Koch

Douglas R Keene

David Wolfe Wagman

Dale D Hunter

Bruce A Morgan

Pamela Olson

Marie-France Champliaud

Toshio Nishiyama

M Peter Marinkovich

Gregory P Lunstrum

Leena Bruckner-Tuderman

Makoto Tsunenaga

Patricia Rousselle

Ritsuko Ehama

Eijiro Adachi

Richard R Libby

Nobuyuji Shioya

Patricia Rouselle

The invention features methods of promoting hair growth in a subject. The methods include inducing or mimicking the effects of Wnt promoted signal transduction, e.g., by increasing the level of Wnt protein or administering an agent which mimics an effect of Wnt promoted signal transduction, e.g., by administering lithium chloride. Methods of inhibiting hair growth are also provided.

Methods of culturing dermal papilla cells

&#x3b2;-netrin nucleic acid molecules and polypeptides are provided. Methods of using the &#x3b2;-netrin nucleic acid molecules and polypeptides are also provided.

&#x3b2; netrin and uses thereof

The invention provides isolated nucleic acids molecules, designated collagen XXII nucleic acid molecules, which encode a novel collagen. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing collagen XXII nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a collagen XXII gene has been introduced or disrupted. The invention still further provides isolated collagen XXII proteins, fusion proteins, antigenic-peptides and anti-collagen XXII antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Collagen XXII, a novel human collagen and uses thereof

&#x3b2;-netrin and uses thereof

Recombinant laminin B1k and fragments thereof.

B1k chain of laminin and methods of use

Methods of modulating hair growth

The invention describes versican activation and modulation of hair growth, e.g., versican expressing dermal papilla cells exhibit hair induction ability.

Versican and epithelial-mesenchymal interaction

The invention provides isolated nucleic acids molecules, designated collagen XXII nucleic acid molecules, which encode a novel collagen. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing collagen XXII nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a collagen XXII gene has been introduced or disrupted. The invention still further provides isolated collagen XXII proteins, fusion proteins, antigenic peptides and anti-collagen XXII antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Antibodies directed against laminin B1k are provided.

The present invention features two members of laminin family, i.e., laminin 13 and laminin 14, the methods of making these molecules, and the methods of using these molecules in treating neural disorders, e.g., retinal disorders. The present invention also features using a preparation of laminin 5 to treat neural disorders, especially disorders associated with retina.

Laminin 5, 13 and 14 and uses thereof

The invention provides methods of evaluating a treatment for its effect on skin. The invention also provides non-human transgenic animals, e.g., mice, having a reporter gene coupled to a skin-metabolism promoter.

Method for evaluating a compound for its effect on skin

The present invention is based on the discovery of a novel member of the laminin family, laminin 12. Accordingly, the present invention features a purified or isolated preparation or a recombinant preparation of laminin 12 which includes an &agr;2 subunit, &bgr;1 subunit and a &ggr;3 subunit.

Laminins and uses thereof

The present invention features a novel member of the laminin family, i.e., laminin 15, the methods of making these molecules, and the methods of using these molecules in treating neural disorders, e.g., retinal disorders.

Laminin 15

The use of laminin-5 to promote formation of basement membrane and to form skin equivalents and to improve grafting of keratinocyte sheets.

Growing community of inventors

Marblehead, MA, United States of America

Robert E Burgeson