Alcon Laboratories, Inc.

Robert E Beck

Yusuf Ali

Haresh G Bhagat

Frank E Brown

Philip D Gressel

Michael J Jobe

Fred M Killinger

Rex C Sport

Ophthalmic suspensions containing brinzolamide or brinzolamide and a beta-blocker and processes for manufacturing the suspensions are disclosed.

Process for manufacturing ophthalmic suspensions

Non-preserved physiological tear compositions comprise the ionic components of normal human tear film in substantially the same amounts and proportions. Novel methods of preparation of these compositions and novel packaging allow the maintenance of the bicarbonate concentration in these compositions.

Physiological tear compositions and methods for their preparation

A method for packaging intraocular lenses, contact lenses and other small, delicate devices which must be stored in a liquid is described. The method utilizes a container having a conically-shaped compartment to package small, delicate devices (e.G., intraocular lenses) in a manner such that the devices may be easily located in the compartment and removed from the container.

Method of packaging intraocular lenses and contact lenses

A package for materials that are to be mixed just prior to use comprises a squeezable container into which is inserted a barrel containing a plunger. One substance to be mixed is placed within the container. The second substance is placed within a compartment formed within the barrel between a pair of pistons having flexible sealing rings. Telescoping of the plunger rod into the barrel causes the upper piston to advance into the compartment. The advancing upper piston exerts hydraulic pressure causing the lower sealing piston to detach from the barrel allowing internal mixing of the substances into a mixed fluid. By squeezing the container side wall, mixed fluid may be dispensed from a forward end of the plunger rod communicating with the container interior through a series of passageways.

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Fort Worth, TX, United States of America

Robert E Beck