Commonwealth Scientific and Industrial Research Organisation

Clinical Genomics Pty. Ltd.

Robert Dunne

Trevor John Lockett

Peter Laurence Molloy

Susanne Kartin Pedersen

Lawrence Charles Lapointe

Ryan Lagerstrom

Mark Berman

Glenn Southwell Brown

Haari Taplo Kiiveri

Lloyd Douglas Graham

Graeme P Young

William J Wilson

Lawrence Clarence Lapointe

Disclosed are nucleic acid, RNA, and protein expression profiles which are indicative of the onset, predisposition to the onset and/or progression of a large intestine neoplasm. More particularly disclosed are nucleic acid molecules, the expression profiles of which are indicative of the onset and/or progression of a colorectal neoplasm, such as an adenoma or an adenocarcinoma. The expression profiles of the present invention are useful in a range of applications including, but not limited to, those relating to the diagnosis and/or monitoring of colorectal neoplasms, such as colorectal adenomas and adenocarcinomas. Further disclosed are methods of screening a subject for the onset, predisposition to the onset and/or progression of a large intestine neoplasm by screening for modulation in the expression profile of the disclosed nucleic acid molecule markers.

Method of diagnosing neoplasms

A method of identifying endmember spectral values from multispectral image data, where each multispectral data value is equal to a sum of mixing proportions of each endmember spectrum. The method comprises the steps of processing the data to obtain a multidimensional simplex having a number of vertices equal to the number of endmembers. The position of each vertex represents a spectrum of one of the endmembers. Processing the data is conducted by providing starting estimates of each endmember spectrum for each image data value. The mixing proportions for each data value is estimated from estimates of the spectra of all the endmembers. The spectrum of each endmember is estimated from estimates of the mixing proportions of the spectra of all the endmembers for each image data value. The estimation steps are repeated until a relative change in the regularised residual sum of squares is sufficiently small. The regularised residual sum of squares includes a term which is a measure of the size of the simplex.

Method of identifying endmember spectral values from hyperspectral image data

Growing community of inventors

Darlington, Australia

Robert Dunne