University of Pennsylvania

Other

Robert Doms

James A Hoxie

Trevor L Hoffman

Michael Endres

Joseph B Rucker

Paul Bates

John Balliet

Dennis L Kolson

Celia C LaBranche

Richard Horuk

Joseph E Hesselgesser

Daryl Faulds

Yiqing Zhou

Branislava Mitrovic

Enveloped virus vectors are described which comprise a cellular virus receptor protein and which are capable of fusing with a cell which comprises a viral envelope protein to which the cellular virus receptor protein is cognate. Enveloped virus vectors comprising a plurality of cellular virus receptor proteins are also described. Methods for making the enveloped virus vectors are described, as are methods of using the enveloped virus vectors. The invention further relates to a lipoparticle comprising a membrane spanning protein, and the lipoparticle can be attached to a sensor surface. The invention relates to methods of producing and using the lipoparticle to, inter alia, assess protein binding interactions.

Method for the production of antibodies that bind to multiple membrane spanning proteins

Method for the preparation of virus-like particles (VLPS) comprising heterologous multiple membrane spanning proteins

Virus-like particles (VLPs) comprising heterologous multiple membrane spanning proteins

The invention relates to novel CD4-independent HIV Envelope proteins and uses therefor.

CD4-independent HIV envelope proteins as vaccines and therapeutics

The orphan seven transmembrane domain receptor, APJ, can function as a coreceptor for cellular infection by the HIV virus. The establishment of cell lines that coexpress CD4 and APJ provide valuable tools for continuing research on HIV infection and the development of anti-HIV therapeutics.

Methods and compositions for modulating the interaction between the APJ receptor and the HIV virus

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Berwyn, PA, United States of America

Robert Doms