Hznp Limited

Nuvo Research Inc.

Tioga Research, Inc.

Robert Dominic King-Smith

John Michael Newsam

Jagat Singh

Edward Thomas Kisak

Bradley S Galer

Maria Burian

Jonathan Wilkin

Lisa Marie Grierson

Joseph Zev Shainhouse

Ilya Feygin

Samir M Mitragotri

The field involves compositions useful for pain relief, including diclofenac solution and gel formulations, in particular methods of use thereof, articles of manufacture and kits that provide novel preclinical, clinical and other information to users.

Treatment of pain with topical diclofenac

Treatment of pain with topical diclofenac compounds

The present invention teaches apparatus () and methods for screening the effect of test formulations on the barrier properties of a membrane (), that are especially beneficial when skin is used as the test membrane (). The apparatus () and methods enable more efficient measurements of skin permeabilization, of the permeation of molecular or particulate entities through skin, and of the absorption and adsorption by skin of ingredients in fluid formulations, together with screening of exfoliation of material from the exterior of the stratum corneum. The apparatus () provide for fluid contact to the skin from both donor and receptor sides, for measurements of skin electrical response in the presence of test formulations, of permeation and permeation enhancement, for the depth profiling of test formulation constituents through the skin, of stratum corneum component disruption, and of loss of material from the stratum corneum.

Apparatus and methods for evaluating the barrier properties of a membrane

Growing community of inventors

San Diego, CA, United States of America

Robert Dominic King-Smith