Amgen Inc.

Unl Holdings LLC

Unitract Syringe Pty Ltd

Robert Decker

Gautam N Shetty

Ian B Hanson

Paul F Bente, Iv

Sean M O'connor

Mark A Destefano

Sheldon B Moberg

Scott Robert Gibson

Daniel Davenport

Margaux Frances Boyaval

Kevin Lee Bokelman

John Christian Love

Daniel Shawn Codd

Ryan Michael Agard

Rajan Ramaswamy

Matthew J Clemente

Scott Beaver

Nicholas J Ciccarelli

Basel Hasan Taha

Devin Sell

Paul F Bente

Iv Bente Paul F

Paul F Bente Iv

Disclosed herein is a wearable drug delivery device including a container filled at least partially with a drug including at least one of a PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) specific antibody, a granulocyte colony-stimulating factor (G-CSF), a sclerostin antibody, or a calcitonin gene-related peptide (CGRP) antibody. The wearable drug delivery device may include a needle and an insertion mechanism configured to insert the needle into a patient. A fluid pathway connector may define a sterile fluid flowpath between the container and the insertion mechanism. Optionally, a cannula initially disposed about the needle may be included. The cannula may be retained in the patient at an injection site created by the needle after the needle is withdrawn from the patient. Methods of assembly and operation are also provided.

Drug delivery device, method of manufacture, and method of use

An insertion mechanism for a drug pump includes an insertion mechanism housing; a manifold guide; an insertion biasing members initially held in an energized state; a retraction biasing member and a hub connected to a proximal end of a needle, wherein the retraction biasing member is held initially in an energized state between the hub and the manifold guide; and a manifold having a septum and a cannula, wherein the annular space between the septum and the cannula defines a manifold header. The needle and cannula are inserted into the body of a user by the insertion biasing member(s), after which only the needle is retracted. Retraction of the needle may open a fluid pathway from the manifold header to the body through the cannula. A drug delivery pump includes an activation mechanism, a drive mechanism, a fluid pathway connection, and the insertion mechanism. Assembly and operation methods are provided.

Insertion mechanism for a drug delivery pump

A cannula for administration of a medicine to a target location includes a tube with at least one nodule disposed along the circumferential surface and spaced at a defined distance from the distal end of the tube. An arrangement for delivery of a medicine to a target location includes the cannula and a pump fluidly coupled to the cannula. The distal end of the cannula may be inserted into a target location until the nodule reaches a surface that limits a depth of penetration before delivery of the medication.

Injectable drug delivery arrangement with controlled delivery cannula position relative to point of delivery

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Dillsburg, PA, United States of America

Robert Decker