University of California

Robert Damoiseaux

Michael E Jung

Richard A Gatti

Jin-Mo Ku

Liutao Du

Robert H Schiestl

Todd O Yeates

Jorge Torres

Jeffery F Miller

Carmen Bertoni

Nan Wang

Yelena O Rivina

Brian T Chamberlain

Kenneth A Bradley

Chi-Lee Charlie Ho

Eugene Gillespie

Hailiang Hu

Yu-Chen Lo

Gladys Completo

Chih-Hung Lai

Dan E McNamara

Silvia Senese

Philip Bulterys

Christopher Todd French

Chung-Ying Lee

Xiangdong W Yang

(Bp) and(Bm) are Tier-1 select pathogens that cause highly lethal human infections with limited therapeutic options. Intercellular spread is a hallmark ofpathogenesis and its prominent ties to virulence make it an attractive therapeutic target. We developed a high-throughput cell-based phenotypic assay and screened ˜220,000 small molecules for their ability to disrupt intercellular spread by, a BSL-2 surrogate for these pathogens. 268 hits were identified, and cross-species validation found 32 hits that also disrupt intercellular spread by Bp and/or Bm. In a fulminant murine model of respiratory melioidosis, treatment with a number of these agents was significantly more effective than ceftazidime, the current drug of choice, for improving patient survival and decreasing bacterial counts in major organs.

Discovery of novel anti-infectives for gram negative pathogens

This disclosure relates to methods of treating cancer (e.g., melanoma) with (MI-181).

Tubulin-binding compounds, compositions and uses related thereto

Disclosed herein inter alia are compositions and methods useful in the treatment of infectious diseases and exposure to toxins.

Protective molecules against anthrax toxin

Premature termination codons readthrough compounds, composition thereof, and methods of making and using the same are provided.

Premature-termination-codons readthrough compounds

Embodiments of the present invention provide compounds and compositions thereof, which are effective for mitigating tissue damage or lethality induced by an agent, and methods of making and using the same.

Compounds and compositions for mitigating tissue damage and lethality

Growing community of inventors

Beverly Hills, CA, United States of America

Robert Damoiseaux