Mayo Foundation for Medical Education and Research

University of Minnesota

Robert D Simari

Shuchong Pan

John C Burnett, Jr

Horng H Chen

David R Holmes, Iii

Gurpreet S Sandhu

Nicole P Sandhu

Rajiv Gulati

David A Berry

Robert S Schwartz

Amir Lerman

Noel M Caplice

Lincoln R Potter

Soumen Jana

Sinny Delacroix

Jr John C Burnett

David R Holmes Iii

Jr David R Holmes

Systems and methods for producing biologic tissues are described. For example, this document provides electrospinning systems and culturing techniques to make biologic heart valve leaflets and fibrosa layers of native valve leaflet having nanofibrous substrate layer(s). In some implementations, a tri-layered leaflet with circumferentially, randomly, and radially oriented nanofibers that mimics morphologies of native leaflets.

Nanofibrous biologic heart valve leaflets and fibrosa layer of a leaflet

Medical devices with surfaces on which viable biologic cells are magnetically attracted and retained are disclosed along with methods of magnetic coating. The medical devices can be located in a carrier liquid containing high concentrations of magnetic cells before or after implantation. The carrier liquid with magnetic cells may be contact with the medical device in vitro or in vivo. In either case, the carrier liquid may have a concentration of magnetic cells that is high enough to facilitate coating of the medical device within an acceptable period of time, e.g., several hours or less. Magnetization of medical devices before, during, and/or after implantation and apparatus for performing the same are disclosed. Degaussing of magnetic medical devices is also disclosed.

Magnetic medical apparatus, kits, and methods

This document provides diuretic and natriuretic polypeptides. For example, this document provides polypeptides having diuretic and/or natriuretic activities. In some cases, a polypeptide provided herein can have diuretic and natriuretic activities, while lacking the ability to lower blood pressure. This document also provides methods and materials for inducing diuretic and/or natriuretic activities within a mammal.

Methods of treatment of heart dysfunctions using diuretic and natriuretic polypeptides

Method of treatment of renal dysfunctions with chimeric natriuretic peptides

Methods and materials for diagnosing and treating heart conditions (e.g., heart failure) and kidney conditions (e.g., kidney failure) are described.

Method for increasing natriuresis or diuresis by isoforms of brain natriuretic peptide

This document relates to methods and materials for treating diseases or disorders associated with elevated platelet counts (e.g., essential thrombocythemia, secondary thrombocytosis, congenital amegakaryocytic thrombocytopenia, sepsis, or asplenism) as well as methods and materials for treating diseases or disorders associated with elevated platelet adhesion to collagen (e.g., acute coronary syndromes, angina pectoris, chronic atherosclerosis, diabetes, or hypertension).

Methods for reducing platelet counts and/or platelet adhesion by administering a GC-B receptor agonist

Systems and methods that provide magnetically-enhanced delivery of therapeutic agents to selected tissue are disclosed. The systems and methods involve the use of carrier devices and release devices and two different magnetic fields to move magnetic particles into selected tissue. Movement of the magnetic particles (and any associated therapeutic agent) into the tissue may be assisted by both magnetic attractive forces as well as magnetic repulsive forces.

Systems and methods for magnetic-assisted therapeutic agent delivery

Kits, apparatus and methods for magnetically coating medical devices with living cells

This document relates to methods and materials involved in preferentially activating natriuretic peptide receptor-C polypeptides. For example, agonists of natriuretic peptide receptor-C polypeptides as well as methods for activating natriuretic peptide receptor-C polypeptides are provided herein.

Natriuretic peptide receptor-C agonists

Isoforms of brain natriuretic peptide

Diuretic and natriuretic polypeptides lacking the blood pressure lowering property

Implantable medical devices that include a non-woven framework are described, as well as methods of using such devices to deliver therapeutic compounds to a patient.

Stent having non-woven framework containing cells

Growing community of inventors

Rochester, MN, United States of America

Robert D Simari