Genentech, Inc.

Other

Washington University

Genetech, Inc.

Deltagen, Inc.

Robert D Klein

Austin L Gurney

William I Wood

Audrey Goddard

Victoria Smith

Arnon Rosenthal

Napoleone Ferrara

Kevin P Baker

Avi J Ashkenazi

Kenneth J Hillan

Mary A Hynes

Frederic J De Sauvage

Nicholas F Paoni

P Mickey Williams

Jeffrey D Milbrandt

Paul T Kotzbauer

Eugene M Johnson

Patricia A Lampe

Mark W Moore

Hanspeter Gerber

Anne M Ryan

Fred DeSauvage

Heidi S Phillips

Thomas J Brennan

Douglas Blanchard

NTNR&#x3b1;, NTNR&#x3b1; extracellular domain (ECD), NTNR&#x3b1; variants, chimeric NTNR&#x3b1; (e.g., NTNR&#x3b1; immunoadhesion), and antibodies which bind thereto (including agonist and neutralizing antibodies) are disclosed. Various uses for these molecules are described, including methods to modulate cell activity and survival by response to NTNR&#x3b1;-ligands, for example NTN, by providing NTNR&#x3b1; to the cell.

Anti-neurturin receptor-A antibody compositions comprising cytokines or neurotrophic factors

The present invention relates to nucleotide sequences, including expressed sequence tags (ESTs), oligonucleotide probes, polypeptides, vectors and host cells expressing, and immunoadhesions and antibodies to mammalian GFR&#x3b1;3, a novel &#x3b1;-subunit receptor of the GDNF (i.e. GFR) receptor family. It further relates to an assay for measuring activation of an &#x3b1;-subunit receptor by detecting tyrosine kinase receptor activation (i.e., autophosphorylation) or other activities related to ligand-induced &#x3b1;-subunit receptor homo-dimerization or homo-oligomerization.

GFR&#x3b1;3 polypeptides

GDNFR&#x3b1;, GDNFR&#x3b1; extracellular domain (ECD), GDNFR&#x3b1; variants, chimeric GDNFR&#x3b1; (e.g., GDNFR&#x3b1; immunoadhesin), and antibodies which bind thereto (including agonist and neutralizing antibodies) are disclosed. Various uses for these molecules are described, including methods to modulate cell activity and survival by response to GDNFR&#x3b1;-ligands, for example GDNF, by providing GDNFR&#x3b1; to the cell. Also provided are methods for using GDNFR&#x3b1;, GDNF, or agonists thereof, separately or in complex, to treat kidney diseases.

Polynucleotides encoding GDNFR&#x3b1;

A novel growth factor, persephin, which belongs to the GDNF/neurturin family of growth factors, is disclosed. The human, mouse and rat amino acid sequences have been identified. Human, mouse and rat persephin genomic DNA sequences have been cloned and sequenced and the respective cDNA sequences identified. In addition, methods for treating degenerative conditions using persephin, methods for detecting persephin gene alterations and methods for detecting and monitoring patient levels of persephin are provided. Methods for identifying additional members of the persephin-neurturin-GDNF family of growth factors are also provided.

Persephin specific antibodies

A unitary molded corner piece, shaped as a right angle V, has a grooved base with slide openings on adjacent sides of the base for receiving and joining together a pair of orthogonally oriented J channel pieces in an assembly. Right angles of the unitary corner piece are spaced apart and defined by spaced vertical walls shaped as an inner and outer angle. Such angles are joined together at the top of the vertical walls by a closed loop. Two orthogonal oriented J channels slide into the corner base while a J channel vertical wall and a J channel top piece slide within the space defined between the vertical walls of the right angle V of the corner piece. A loose free end of the J channel fits within the adjoining loop of the corner piece. Reinforcing ribs in a J channel receiving pocket both frictionally hold a J channel inserted into said corner piece and guide water as a trough.

Unitary molded corner piece method and apparatus

GDNF receptor&#x3b1;

Polynucleotides encoding GFR&#x3b1;3

Polynucleotides encoding human persephin and related growth factors

This invention provides novel nucleotide constructs. Also provided are methods for making DNA constructs useful for introducing sequences into and disrupting the function of a gene in a cell, particularly an embryonic stem cell.

Methods of creating constructs useful for introducing sequences into embryonic stem cells

NTNR&agr;, NTNR&agr; extracellular domain (ECD), NTNR&agr; variants, chimeric NTNR&agr; (e.g., NTNR&agr; immunoadhesion), and antibodies which bind thereto (including agonist and neutralizing antibodies) are disclosed. Various uses for these molecules are described, including methods to modulate cell activity and survival by response to NTNR&agr;-ligands, for example NTN, by providing NTNR&agr; to the cell.

Neurturin receptor

Persephin and related growth factors

GDNFR&agr;, GDNFR&agr; extracellular domain (ECD), GDNFR&agr; variants, chimeric GDNFRae (e.g., GDNFR&agr; immunoadhesin), and antibodies which bind thereto (including agonist and neutralizing antibodies) are disclosed. Various uses for these molecules are described, including methods to modulate cell activity and survival by response to GDNFR&agr;-ligands, for example GDNF, by providing GDNFR&agr; to the cell. Also provided are methods for using GDNFR&agr;, GDNF, or agonists thereof, separately or in complex, to treat kidney diseases.

GDNF receptor

NTNR&agr;, NTNR&agr; extracellular domain (ECD), NTNR&agr; variants, chimeric NTNR&agr; (e.g., NTNR&agr; immunoadhesin), and antibodies which bind thereto (including agonist and neutralizing antibodies) are disclosed. Various uses for these molecules are described, including methods to modulate cell activity and survival by response to NTNR&agr;-ligands, for example NTN. by providing NTNR&agr; to the cell.

NTNR&agr;, NTNR&agr; extracellular domain (ECD), NTNR&agr; variants, chimeric NTNR&agr; (e.g., NTNR&agr; immunoadhesin), and antibodies which bind thereto (including agonist and neutralizing antibodies) are disclosed. Various uses for these molecules are described, including methods to modulate cell activity and survival by response to NTNR&agr;-ligands, for example NTN, by providing NTNR&agr; to the cell.

Growing community of inventors

Palo Alto, CA, United States of America

Robert D Klein