Orchid Biosciences, Inc.

Other

Robert D Juncosa

Johannes Dapprich

Richard A Scribner

Rene Bongard

Rolf E Swenson

Chao Lin

Sheila H DeWitt

Richard J Davies

Dale Robert Pfost

Sheldon M Kugelmass

Gary J Schnerr

A genetic analysis device particularly for determining the presence or absence of Single Nucleotide Polymorphisms (SNPs) within specific sequences of DNA. The device includes a housing, at least one glass slide member, and an elastomeric member with channels thereon. Oligo arrays are spotted on the glass slide member(s) and subjected to DNA samples, reagents or the like. A plurality of openings or ports allow entry of samples, reagents or wash materials, while a plurality of exit ports or openings allow removal of such materials. The assay devices can be used for multiple samples or a single sample. A plurality of synthesis devices can be positioned in a support base in order to allow sampling in an automated manner. The synthesis devices can be provided in a 96 well microtiter format.

Genetic assay system

Multiple fluid sample processors and systems for high throughput chemical synthesis and biological assays and/or processing. A multi-layered fluidic array having microchannels, reservoirs and reaction wells is subject to robotic and automated handling. A pressure pumping system is utilized for fluid delivery and control through the synthesis process. The sizes of the micro-sized channels, apertures, and valves are adjusted to optimize fluid distribution and channel filling. The fluid sample processors can be grouped together in a microtiter format to increase the speed, quantity and efficiency of the processing.

Multiple fluid sample processor and system

Tissue (,) from the colon or bowel is pretreated with a Ringers solution and mounted onto a ring (,) submerged in oxygenated Ringers solution (,), with first and second current electrodes (,) and first and second voltage electrodes (,) positioned within the solution (,) closely adjacent the tissue. A sequence of current pulses of different frequencies (,) covering a broad frequency range are applied via electrodes (,) to the tissue and corresponding impedance and resistance values are obtained (,). Comparison of impedance/resistance values establishes separate and distinct ranges of values for normal, cancerous and premalignant tissues.

Method for the detection of cancer and premalignancy conditions thereof

Genetic analysis device

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Yardley, PA, United States of America

Robert D Juncosa